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Ann Thorac Surg 1998;66:2145-2152
© 1998 The Society of Thoracic Surgeons
a Department of Cardiothoracic Surgery, Imperial College of Science, Technology and Medicine, University of London, Hammersmith Hospital, London, England, United Kingdom
Address reprint requests to Dr Taylor, Department of Cardiothoracic Surgery, Imperial College of Science, Technology and Medicine, University of London, Hammersmith Hospital, London W12 OHS, England
Platelets are the smallest of the blood cells and are known to be activated during cardiopulmonary bypass. They play a role in many associated complications. Both quantitative and qualitative platelet defects have been demonstrated, resulting in microvascular hemorrhage and thromboembolism. As their interactions with endothelium and other blood cells are unraveled, the important contribution they make toward the systemic inflammatory response to operation seen in cardiopulmonary bypass is increasingly evident. In this review, we consider platelet activation during cardiopulmonary bypass, the resultant clinical effects, and potential approaches to therapy and prevention.
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