HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Brett C. Sheridan James M. Brown David N. Campbell Frederick L. Grover Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sheridan, B. C. Articles by Grover, F. L. Search for Related Content PubMed PubMed Citation Articles by Sheridan, B. C. Articles by Grover, F. L.

Ann Thorac Surg 1998;66:1755-1758
© 1998 The Society of Thoracic Surgeons

---

Original articles: general thoracic

Acute and chronic effects of bilateral lung transplantation without cardiopulmonary bypass on the first transplanted lung

^a Divisions of Cardiothoracic Surgery, Pulmonary Medicine, and Department of Radiology, University of Colorado Health Sciences Center, and Department of Veteran’s Affairs Medical Center, Denver, Colorado, USA

Address reprint requests to Dr Grover, Cardiothoracic Surgery, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C-310, Denver, CO 80262

Presented at the Forty-fourth Annual Meeting of the Southern Thoracic Surgical Association, Naples, FL, Nov 6–8, 1997.

Background. Bilateral lung transplantation (BLT) without cardiopulmonary bypass (CPB) may exacerbate reperfusion injury to the initially engrafted lung because of increases in pulmonary flow during implantation of the second graft.

Methods. In a retrospective review of 23 BLT patients, we hypothesized that BLT without CPB injures the first transplanted lung measured by acute and late graft dysfunction compared to the second transplanted lung. Of the 23 BLT, 19 underwent transplantation without CPB while 4 patients were placed on CPB secondary to hemodynamic instability.

Results. Acute graft function was assessed by radiographic scoring of lung quadrants (blinded radiologist; 0 = no infiltrate; 1 = infiltrate; maximum = 2 per lung) and by arterial/alveolar oxygen tension ratios (PaO₂/FiO₂) ratios. Late graft function was evaluated by quantitative perfusion scan. Lung perfusion was graded as abnormal if less than 50% on the right or less than 45% on the left (Fisher’s exact). Radiographic scores were not different between first and second implanted lungs at 1 and 24 hours, PaO₂/FiO₂ ratios at 1 and 24 hours were 273 ± 26 and 312 ± 23, respectively, and perfusion scans at 3 and 12 months revealed normal differential blood flow.

Conclusions. These findings suggest no acute or chronic differences occur between the first or second transplanted lung completed without CPB.

This article has been cited by other articles:

				C. Aigner, W. Wisser, S. Taghavi, G. Lang, P. Jaksch, D. Czyzewski, and W. Klepetko Institutional experience with extracorporeal membrane oxygenation in lung transplantation Eur. J. Cardiothorac. Surg., March 1, 2007; 31(3): 468 - 474. [Abstract] [Full Text] [PDF]

				T. Oto, A. P. Griffiths, B. J. Levvey, T. J. Williams, and G. I. Snell Unilateral radiographic abnormalities after bilateral lung transplantation: Exclusion from the definition of primary graft dysfunction? J. Thorac. Cardiovasc. Surg., December 1, 2006; 132(6): 1441 - 1446. [Abstract] [Full Text] [PDF]

				D.V. Pilcher, C.D. Scheinkestel, G.I. Snell, A. Davey-Quinn, M.J. Bailey, and T.J. Williams High central venous pressure is associated with prolonged mechanical ventilation and increased mortality after lung transplantation J. Thorac. Cardiovasc. Surg., April 1, 2005; 129(4): 912 - 918. [Abstract] [Full Text] [PDF]

				S. S. Huerd, T. N. Hodges, F. L. Grover, J. R. Mault, M. B. Mitchell, D. N. Campbell, S. Aziz, P. Chetham, F. Torres, and M. R. Zamora SECONDARY PULMONARY HYPERTENSION DOES NOT ADVERSELY AFFECT OUTCOME AFTER SINGLE LUNG TRANSPLANTATION J. Thorac. Cardiovasc. Surg., March 1, 2000; 119(3): 458 - 465. [Abstract] [Full Text] [PDF]