ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
A. Mark Jayawant
Ralph J. Damiano, Jr
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jayawant, A. M.
Right arrow Articles by Damiano, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jayawant, A. M.
Right arrow Articles by Damiano, R. J., Jr

Ann Thorac Surg 1998;66:1329-1335
© 1998 The Society of Thoracic Surgeons

Original articles: cardiovascular

The superiority of pinacidil over adenosine cardioplegia in blood-perfused isolated hearts

A. Mark Jayawant, MDa, Ralph J. Damiano, Jr, MDb

a Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Virginia, Richmond, Virginia, USA
b Section of Cardiothoracic Surgery, The Milton S. Hershey Medical Center, Pennsylvania State-Geisinger Health System, Hershey, Pennsylvania, USA

Accepted for publication May 14, 1998.

Address reprint requests to Dr Damiano, Section of Cardiothoracic Surgery, The Milton S. Hershey Medical Center, Pennsylvania State-Geisinger Health System, PO Box 850, Hershey, PA 17033
e-mail: (damiano{at}surg.hmc.psghs.edu)

Background. Our laboratory has shown that the potassium-channel opener pinacidil is an effective cardioplegic agent. A theoretical benefit of cardioplegia with potassium-channel openers is that it arrests the heart at hyperpolarized membrane potentials, a state of minimal metabolic requirement. This study was designed to examine another nondepolarizing agent, adenosine, and to test the hypothesis that it could provide comparable cardioprotection or augment potassium-channel opener cardioplegia.

Methods. Using the blood-perfused Langendorff technique, isolated rabbit hearts were arrested for 30 minutes of global normothermic ischemia. Cardioplegia consisted of either Krebs-Henseleit solution alone (control) or with pinacidil (50 µmol/L), adenosine (200 µmol/L to 1 mmol/L), or pinacidil + adenosine (200 µmol/L). Recovery of developed pressure and coronary flow were recorded.

Results. Postischemic functional recovery for control, pinacidil, adenosine, and adenosine + pinacidil groups was 44.1% ± 3.4%, 59.5% ± 5.2% (p < 0.05 versus control), 37.0% ± 4.5%, and 56.0% ± 2.9%, respectively.

Conclusions. Adenosine, alone or as adjunct to pinacidil cardioplegia, was not an effective cardioplegic agent, despite shorter times to electromechanical arrest than control. The ineffectiveness of adenosine suggests that the cardioprotective properties of potassium-channel openers involve mechanisms other than the avoidance of membrane depolarization.




This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
G. P. Dobson and M. W. Jones
Adenosine and lidocaine: a new concept in nondepolarizing surgical myocardial arrest, protection, and preservation
J. Thorac. Cardiovasc. Surg., March 1, 2004; 127(3): 794 - 805.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1998 by The Society of Thoracic Surgeons.