HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Jennifer S. Lawton Ralph J. Damiano, Jr Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lawton, J. S. Articles by Damiano, R. J. Search for Related Content PubMed PubMed Citation Articles by Lawton, J. S. Articles by Damiano, R. J., Jr

Ann Thorac Surg 1998;66:768-773
© 1998 The Society of Thoracic Surgeons

---

Original articles: Cardiovascular

The adenosine-triphosphate–sensitive potassium-channel opener pinacidil is effective in blood cardioplegia

^a Department of Surgery, Medical College of Virginia, Richmond, Virginia, USA

Accepted for publication March 31, 1998.

Address reprint requests to Dr Damiano, The Milton S. Hershey Medical Center, PO Box 850, Hershey, PA 17033
e-mail: (damiano{at}surg.hmc.psu.edu)

Background. This study was designed to evaluate the adenosine-triphosphate–sensitive potassium channel opener pinacidil as a blood cardioplegic agent.

Methods. Using a blood-perfused, parabiotic, Langendorff rabbit model, hearts underwent 30 minutes of normothermic ischemia protected with blood cardioplegia (St. Thomas’ solution [n = 8] or Krebs-Henseleit solution with pinacidil [50 µmol/L, n = 8]) and 30 minutes of reperfusion. Percent recovery of developed pressure, mechanical arrest, electrical arrest, reperfusion ventricular fibrillation, percent tissue water, and myocardial oxygen consumption were compared.

Results. The percent recovery of developed pressure was not different between the groups (52.3 ± 5.9 and 52.8 ± 6.9 for hyperkalemic and pinacidil cardioplegia, respectively). Pinacidil cardioplegia was associated with prolonged electrical and mechanical activity (14.4 ± 8.7 and 6.1 ± 3.9 minutes), compared with hyperkalemic cardioplegia (1.1 ± 0.6 and 1.1 ± 0.6 minutes, respectively; p < 0.05). Pinacidil cardioplegia was associated with a higher reperfusion myocardial oxygen consumption (0.6 ± 0.1 versus 0.2 ± 0.0 mL/100 g myocardium/beat; p < 0.05) and a higher percent of tissue water (79.6% ± 0.7% versus 78.6% ± 1.2%; p < 0.05).

Conclusions. Systolic recovery was not different between groups, demonstrating comparable effectiveness of pinacidil and hyperkalemic warm blood cardioplegia.

This article has been cited by other articles:

				S. Kobayashi, Y. Yoshikawa, S. Sakata, C. Takenaka, H. Hagihara, Y. Ohga, T. Abe, S. Taniguchi, and M. Takaki Left ventricular mechanoenergetics after hyperpolarized cardioplegic arrest by nicorandil and after depolarized cardioplegic arrest by KCl Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1072 - H1080. [Abstract] [Full Text] [PDF]

				T. Steensrud, D. Nordhaug, O.P. Elvenes, C. Korvald, and D.G. Sorlie Superior myocardial protection with nicorandil cardioplegia Eur. J. Cardiothorac. Surg., May 1, 2003; 23(5): 670 - 677. [Abstract] [Full Text] [PDF]

				Y. Toyoda, I. Friehs, R. A. Parker, S. Levitsky, and J. D. McCully Differential role of sarcolemmal and mitochondrial KATP channels in adenosine-enhanced ischemic preconditioning Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2694 - H2703. [Abstract] [Full Text] [PDF]