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Ann Thorac Surg 1998;66:547-548
© 1998 The Society of Thoracic Surgeons

Case Reports

Mediastinal germ cell tumor in a child with precocious puberty and Klinefelter syndrome

Gregory G. Bebb, MDa, Frederic W. Grannis, Jr, MDa, Isaac B. Paz, MDa, Marilyn L. Slovak, PhDa, Robert Chilcote, MDa

a Departments of General and Oncologic Surgery, Thoracic Surgery, Cytogenetics, and Pediatric Oncology, City of Hope National Medical Center, Duarte, California, USA

Accepted for publication February 12, 1998.

Address reprint requests to Dr Grannis, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010
e-mail: (fgrannis {at}smtplink.coh.org)

An 8-year-old boy presented with precocious puberty and a mediastinal mass. A computer search showed that this rare presentation is most common with germ cell tumor of the mediastinum in children with Klinefelter syndrome. The tumor was completely resected after preoperative chemotherapy, and the patient is well 2 years after the operation. In patients with Klinefelter syndrome, germ cell tumors are 50 times more common than in patients without Klinefelter syndrome, usually contain nonseminomatous elements, present at an earlier age, and are seldom testicular in location.






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Copyright © 1998 by The Society of Thoracic Surgeons.