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Ann Thorac Surg 1998;66:532-534
© 1998 The Society of Thoracic Surgeons

Original articles: cardiovascular

Decreased exhaled nitric oxide may be a marker of cardiopulmonary bypass–induced injury

Maurice Beghetti, MDa, Philip E. Silkoff, MRCPb, Marlova Caramori, MDb, Helen M. Holtby, MDc, Arthur S. Slutsky, MDb, Ian Adatia, MB, ChBa,d

a Division of Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
c Department of Anesthesia, The Hospital for Sick Children, University of Toronto, Toronto, Canada
d Department of Critical Care Medicine, The Hospital for Sick Children University of Toronto, Toronto, Canada
b Division of Respiratory Medicine and Departments of Pediatrics, Anesthesia, and Critical Care Medicine, University of Toronto, Toronto, Canada

Accepted for publication March 20, 1998.

Address reprint requests to Dr Adatia, Critical Care Medicine and Cardiology, The Hospital for Sick Children, 555 University Ave, Toronto, Ont M5J 1X8, Canada
e-mail: (iadatia{at}sickkids.on.ca)

Background. Nitric oxide is an endothelium-derived vasodilator. Cardiopulmonary bypass may induce transient pulmonary endothelial dysfunction with decreased nitric oxide release that contributes to postoperative pulmonary hypertension and lung injury. Exhaled nitric oxide levels may reflect, in part, endogenous production from the pulmonary vascular endothelium.

Methods. We measured exhaled nitric oxide levels before and 30 minutes after cardiopulmonary bypass in 30 children with acyanotic congenital heart disease and left-to-right intracardiac shunts undergoing repair.

Results. Exhaled nitric oxide levels decreased by 27.6% ± 5.6% from 7 ± 0.8 to 4.4 ± 0.5 ppb (p < 0.05) 30 minutes after cardiopulmonary bypass despite a reduction in hemoglobin concentration.

Conclusions. The decrease in exhaled nitric oxide levels suggests reduced nitric oxide synthesis as a result of pulmonary vascular endothelial or lung epithelial injury. This may explain the efficacy of inhaled nitric oxide in the treatment of postoperative pulmonary hypertension. Furthermore, strategies aimed at minimizing endothelial dysfunction and augmenting nitric oxide production during cardiopulmonary bypass may decrease the incidence of postoperative pulmonary hypertension. Exhaled nitric oxide levels may be useful to monitor both cardiopulmonary bypass–induced endothelial injury and the effect of strategies aimed at minimizing such injury.




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