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Ann Thorac Surg 1998;66:466-470
© 1998 The Society of Thoracic Surgeons

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Original articles: cardiovascular

Effects of cardioplegic solutions on the vasoreactivity of the internal mammary artery

^a Department of Cardiovascular Surgery, Broussais Hospital, Paris, France
^b Servier Research Institute, Suresnes, France

Accepted for publication March 21, 1998.

Address reprint requests to Dr Fabiani, Département de Chirurgie Cardio-vasculaire, Hôpital Broussais, 96, rue Didot, 75014 Paris, France

Background. During free internal mammary artery grafting, cardioplegia administration can be performed through the internal mammary artery. The present study examined whether cardioplegic solutions produce arterial graft constriction and functional endothelial damage.

Methods. Forty internal mammary artery segments from 10 patients were incubated in Krebs solution (n = 10), University of Wisconsin solution (n = 10), Broussais Hospital solution (n = 10), or blood cardioplegia (n = 10).

Results. There was a significant difference in sensitivity to norepinephrine between segments in Krebs solution and those in University of Wisconsin solution or Broussais Hospital solution but not segments in blood cardioplegia. There was a significant difference in relaxation to acetylcholine between segments in Krebs solution and those in the three other cardioplegic solutions and between those in blood cardioplegia and segments in University of Wisconsin solution or Broussais Hospital solution. There was no significant difference in relaxation to sodium nitroprusside between segments in any of the solutions.

Conclusions. These experiments suggest that storage in the different cardioplegic solutions studied does not preserve the initial vasoreactivity of the internal mammary artery. However, blood cardioplegia appears to be less deleterious in regard to endothelial and myogenic vascular function.

This article has been cited by other articles:

				P. J. Pearson and H. V. Schaff Effects of cardioplegic solutions on vasoreactivity of the internal mammary artery Ann. Thorac. Surg., August 1, 1998; 66(2): 311 - 312. [Full Text] [PDF]