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Ann Thorac Surg 1998;66:268-270
© 1998 The Society of Thoracic Surgeons

Case Reports

Cardiopulmonary bypass in a gravid patient: perioperative changes in endothelin levels

James L. Zellner, MDa, Scott B. Kribbs, BSa, B. Hugh Dorman, MD, PhDa, Francis G. Spinale, MD, PhDa

a Departments of Surgery and Anesthesiology, Medical University of South Carolina, Charleston, South Carolina, USA

Accepted for publication February 10, 1998.

Address reprint requests to Dr Spinale, Cardiothoracic Surgery, Rm 418 CSB, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425

Transient elevations of the potent vasoconstrictive peptide endothelin have been reported to occur with the institution of cardiopulmonary bypass. We measured plasma endothelin levels in a 24-year-old gravid patient undergoing a mitral valve replacement operation. Plasma endothelin levels increased by more than 250% in the first 24 hours postoperatively and remained elevated above baseline values at 36 hours postoperatively.




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