| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1998;66:12-18
© 1998 The Society of Thoracic Surgeons
a Division of Cardiothoracic Surgery, McGill University, Montreal, Canada
b Department of Pathology, McGill University, Montreal, Canada
c Division of Plastic Surgery, McGill University, Montreal, Canada
Address reprint requests to Dr Chiu, Montreal General Hospital, Room C9.169, 1650 Pine Ave, Montreal, Quebec, H3G 1A4, Canada
e-mail: (mdiu{at}musica.mcgill.ca)
The Thoracic Surgery Directors Association (TSDA) Resident Research Award, sponsored by Medtronic, Inc, was established in 1990 to encourage resident research in cardiothoracic surgery. Abstracts submitted to The Society of Thoracic Surgeons (STS) Program Committee representing research performed by residents were forwarded to the TSDA to be considered for this award. The abstracts were reviewed by the TSDA Executive Committee, consisting of Mark B. Orringer, President, Gordon N. Olinger, President-Elect, Edward D. Verrier, Secretary/Treasurer, and Frederick L. Grover and D. Glenn Pennington, Executive Committeemen. The eighth TSDA Resident Research Award was given to Marc P. Pelletier, MD, a cardiac surgery resident in the Department of Surgery, McGill University, Montreal, Quebec, Canada, who completed a Thoracic Surgery Research Fellowship in the Department of Surgery in June 1997. He received a monetary award of $2,500 and an engraved desktop award. The TSDA, with support by Medtronic, Inc, makes this award annually, using the above selection procedure. The resident author of the selected study is recognized at the STS meeting.
Presented at the Thirty-fourth Annual Meeting of The Society of Thoracic Surgeons, New Orleans, LA, Jan 26–28, 1998.
Background. The mechanism by which transmyocardial revascularization (TMR) exerts a beneficial effect remains unknown. We hypothesize that the myocardial punctures of TMR cause a myocardial injury, leading to an angiogenic response mediated by a number of growth factors.
Methods. Fifty-three rats underwent ligation of the left coronary artery. Group I (n = 25) served as controls, whereas group II (n = 28) underwent concomitant TMR by the creation of six transmural channels with a 25-gauge needle in the ischemic zone. Surviving animals in both groups were sacrificed at intervals of 1, 2, 4, and 8 weeks (n = 5 in each subgroup). Immunohistochemistry in the infarct areas was performed for factor VIII to assess vascular density. Immunohistochemistry using specific antibodies was also performed for transforming growth factor-ß, basic-fibroblast growth factor, and vasoendothelial growth factor. Growth factor expression was quantitated by comparing areas of staining (in mm2) with computerized morphometric analysis.
Results. Mortality was similar in both groups (5/25 versus 8/28; not significant). Group II had significantly greater vascular density than group I (5.65 versus 4.06 vessels/high-power field; p < 0.001), with a peak at 1 week postoperatively (9.12 versus 5.56 vessels/high-power field; p < 0.0001) in both groups. Overall, levels of both transforming growth factor-ß and basic-fibroblast growth factor were significantly higher in the TMR group compared with the control group (0.207 versus 0.141 mm2/mm2, p < 0.05; and 0.125 versus 0.099 mm2/mm2, p < 0.05).
Conclusions. This model of TMR is associated with a significant angiogenic response, which appears to be mediated by the release of certain angiogenic growth factors such as transforming growth factor-ß and basic-fibroblast growth factor. With the long-term patency of laser-created myocardial channels in clinical TMR increasingly in doubt, its mechanism of myocardial revascularization may be similar to that observed in our model.
This article has been cited by other articles:
|
|
 |
|
  T Okamura, N Ishibashi, Y Iwata, D Zurakowski, and R. Jonas Aprotinin concentration varies significantly according to cardiopulmonary bypass conditions Perfusion, November 1, 2008; 23(6): 355 - 360. [Abstract] [PDF]
|
|
|
|
 |
|
 J. D. Puskas, P. D. Kilgo, O. M. Lattouf, V. H. Thourani, W. A. Cooper, T. A. Vassiliades, E. P. Chen, J. D. Vega, and R. A. Guyton Off-Pump Coronary Bypass Provides Reduced Mortality and Morbidity and Equivalent 10-Year Survival Ann. Thorac. Surg., October 1, 2008; 86(4): 1139 - 1146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Boodhwani, H. J. Nathan, T. G. Mesana, F. D. Rubens, and Cardiotomy Investigators Effects of Shed Mediastinal Blood on Cardiovascular and Pulmonary Function: A Randomized, Double-Blind Study Ann. Thorac. Surg., October 1, 2008; 86(4): 1167 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Horvath and Y. Zhou Transmyocardial Laser Revascularization and Extravascular Angiogenetic Techniques to Increase Myocardial Blood Flow Card. Surg. Adult, January 1, 2008; 3(2008): 733 - 752. [Full Text]
|
|
|
|
 |
|
 D. Spiegelstein, C. Kim, Y. Zhang, G. Li, R. D. Weisel, R.-K. Li, and T. M. Yau Combined transmyocardial revascularization and cell-based angiogenic gene therapy increases transplanted cell survival Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3311 - H3316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Puskas, F. H. Edwards, P. A. Pappas, S. O'Brien, E. D. Peterson, P. Kilgo, and T. B. Ferguson Jr Off-Pump Techniques Benefit Men and Women and Narrow the Disparity in Mortality After Coronary Bypass Grafting Ann. Thorac. Surg., November 1, 2007; 84(5): 1447 - 1456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Puskas and M. Steele Would You Like Some Cardiopulmonary Bypass With Your Coronary Revascularization? Circulation, October 16, 2007; 116(16): 1756 - 1758. [Full Text] [PDF]
|
|
|
|
|
|
J. D. Puskas, P. D. Kilgo, M. Kutner, S. V. Pusca, O. Lattouf, and R. A. Guyton Off-Pump Techniques Disproportionately Benefit Women and Narrow the Gender Disparity in Outcomes After Coronary Artery Bypass Surgery Circulation, September 11, 2007; 116(11_suppl): I-192 - I-199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tasse and R. Arora Transmyocardial Revascularization: Peril and Potential Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2007; 12(1): 44 - 53. [Abstract] [PDF]
|
|
|
|
|
|
M. R. Hoda, H. El-Achkar, E. Schmitz, T. Scheffold, H. O. Vetter, and R. De Simone Systemic Stress Hormone Response in Patients Undergoing Open Heart Surgery With or Without Cardiopulmonary Bypass Ann. Thorac. Surg., December 1, 2006; 82(6): 2179 - 2186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Enomoto, M Yoshiyama, T Omura, R Matsumoto, T Kusuyama, D Nishiya, Y Izumi, K Akioka, H Iwao, K Takeuchi, et al. Microbubble destruction with ultrasound augments neovascularisation by bone marrow cell transplantation in rat hind limb ischaemia Heart, April 1, 2006; 92(4): 515 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Seeburger, J. Hoffmann, H. P. Wendel, G. Ziemer, and H. Aebert Gene Expression Changes in Leukocytes During Cardiopulmonary Bypass Are Dependent on Circuit Coating Circulation, August 30, 2005; 112(9_suppl): I-224 - I-228. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wippermann, J. M. Albes, M. Hartrumpf, M. Kaluza, R. Vollandt, R. Bruhin, and T. Wahlers Comparison of minimally invasive closed circuit extracorporeal circulation with conventional cardiopulmonary bypass and with off-pump technique in CABG patients: selected parameters of coagulation and inflammatory system Eur. J. Cardiothorac. Surg., July 1, 2005; 28(1): 127 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Feindt, J. Litmathe, U. Boeken, and E. Gams Anticoagulation during extracorporeal circulation under conditions of an ongoing systemic inflammatory response syndrome: effects of heparin Perfusion, January 1, 2005; 20(1): 11 - 15. [Abstract] [PDF]
|
|
|
|
|
|
M. Galinanes, M. Loubani, P. R. Sensky, A. Hassouna, G. R. Cherryman, J. N. Leverment, and N. J. Samani Efficacy of transmyocardial laser revascularization and thoracic sympathectomy for the treatment of refractory angina Ann. Thorac. Surg., July 1, 2004; 78(1): 122 - 128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Bridges, K. A. Horvath, W. C. Nugent, D. M. Shahian, C. K. Haan, R. J. Shemin, K. B. Allen, and F. H. Edwards The Society of Thoracic Surgeons practice guideline series: transmyocardial laser revascularization Ann. Thorac. Surg., April 1, 2004; 77(4): 1494 - 1502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rossi, G. Sganga, M. Mazzone, V. Valenza, S. Guarneri, G. Portale, L. Carbone, L. Gatta, C. Pioli, M. Sanguinetti, et al. Cardiopulmonary bypass in man: role of the intestine in a self-limiting inflammatory response with demonstrable bacterial translocation Ann. Thorac. Surg., February 1, 2004; 77(2): 612 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Loubani, D. Chin, J. N. Leverment, and M. Galinanes Mid-term results of combined transmyocardial laser revascularization and coronary artery bypass Ann. Thorac. Surg., October 1, 2003; 76(4): 1163 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Saririan and M. J. Eisenberg Myocardial laser revascularization for the treatment of end-stage coronary artery disease J. Am. Coll. Cardiol., January 15, 2003; 41(2): 173 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. P. Eising, M. Pfauder, M. Niemeyer, P. Tassani, H. Schad, R. Bauernschmitt, and R. Lange Retrograde autologous priming: is it useful in elective on-pump coronary artery bypass surgery? Ann. Thorac. Surg., January 1, 2003; 75(1): 23 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ruel, R. A. Kelly, and F. W. Sellke Therapeutic Angiogenesis, Transmyocardial Laser Revascularization, and Cell Therapy Card. Surg. Adult, January 1, 2003; 2(2003): 715 - 750. [Full Text]
|
|
|
|
|
|
M. Huikeshoven, J. F. Beek, J. A.P. van der Sloot, R. Tukkie, J. van der Meulen, and M. J.C. van Gemert 35 years of experimental research in transmyocardial revascularization: what have we learned? Ann. Thorac. Surg., September 1, 2002; 74(3): 956 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Hughes, S. S. Biswas, B. Yin, D. V. Baklanov, B. H. Annex, R. E. Coleman, T. R. DeGrado, C. K. Landolfo, K. P. Landolfo, and J. E. Lowe A comparison of mechanical and laser transmyocardial revascularization for induction of angiogenesis and arteriogenesis in chronically ischemic myocardium J. Am. Coll. Cardiol., April 3, 2002; 39(7): 1220 - 1228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hamano, T.-S. Li, T. Kobayashi, K. Hirata, M. Yano, M. Kohno, and M. Matsuzaki Therapeutic angiogenesis induced by local autologous bone marrow cell implantation Ann. Thorac. Surg., April 1, 2002; 73(4): 1210 - 1215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Laham, M. Simons, J. D. Pearlman, K. K. L. Ho, and D. S. Baim Magnetic resonance imaging demonstrates improved regional systolic wall motion and thickening and myocardial perfusion of myocardial territories treated by laser myocardial revascularization J. Am. Coll. Cardiol., January 2, 2002; 39(1): 1 - 8. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Kalweit, J. D. Schipke, E. Godehardt, and E. Gams Changes in coronary vessel resistance during postischemic reperfusion and effectiveness of nitroglycerin J. Thorac. Cardiovasc. Surg., November 1, 2001; 122(5): 1011 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Hamawy, L. Y. Lee, S. A. Samy, D. R. Polce, M. Szulc, M. Vazquez, and T. K. Rosengart Transmyocardial laser revascularization dose response: enhanced perfusion in a porcine ischemia model as a function of channel density Ann. Thorac. Surg., September 1, 2001; 72(3): 817 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Saito, M. P. Pelletier, H. Shennib, and A. Giaid Nitric oxide system in needle-induced transmyocardial revascularization Ann. Thorac. Surg., July 1, 2001; 72(1): 129 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Tabibiazar and S.G Rockson Angiogenesis and the ischaemic heart Eur. Heart J., June 1, 2001; 22(11): 903 - 918. [PDF]
|
|
|
|
 |
|
 S. Fuchs and R. Kornowski Transepicardial or transendocardial injury: controversies regarding angiogenic potential and mechanism of action Cardiovasc Res, February 16, 2001; 49(3): 582 - 587. [Full Text] [PDF]
|
|
|
|
|
|
A. S. Bortone, D. D'Agostino, S. Schena, G. Rubini, M. Viecca, V. Sardaro, A. Tucci, and L. de Luca Tupputi Schinosa Instrumental validation of percutaneous transmyocardial revascularization: follow-up data at one year Ann. Thorac. Surg., September 1, 2000; 70(3): 1115 - 1118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Bortone, D. D'Agostino, S. Schena, G. Rubini, P. Brindicci, V. Sardaro, A. D'Addabbo, and L. de Luca Tupputi Schinosa Inflammatory response and angiogenesis after percutaneous transmyocardial laser revascularization Ann. Thorac. Surg., September 1, 2000; 70(3): 1134 - 1138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Y. Lee, M. F. O'Hara, E. B. Finnin, R. Hachamovitch, M. Szulc, P. D. Kligfield, P. M. Okin, O. W. Isom, and T. K. Rosengart Transmyocardial laser revascularization with excimer laser: clinical results at 1 year Ann. Thorac. Surg., August 1, 2000; 70(2): 498 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Hughes, A. P. Kypson, B. H. Annex, B. Yin, J. D. St. Louis, S. S. Biswas, R. E. Coleman, T. R. DeGrado, C. L. Donovan, K. P. Landolfo, et al. Induction of angiogenesis after TMR: a comparison of holmium:YAG, CO2, and excimer lasers Ann. Thorac. Surg., August 1, 2000; 70(2): 504 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Bridges Myocardial laser revascularization: the controversy and the data Ann. Thorac. Surg., February 1, 2000; 69(2): 655 - 662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Humphrey and R. Arena Surgical Innovations for Chronic Heart Failure in the Context of Cardiopulmonary Rehabilitation Physical Therapy, January 1, 2000; 80(1): 61 - 69. [Full Text] [PDF]
|
|
|
|
|
|
P. Whittaker Transmyocardial revascularization: the fate of myocardial channels Ann. Thorac. Surg., December 1, 1999; 68(6): 2376 - 2382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Rimoldi, S. M. Burns, S. D. Rosen, T. E. Wistow, P. M. Schofield, G. Taylor, and P. G. Camici Measurement of Myocardial Blood Flow With Positron Emission Tomography Before and After Transmyocardial Laser Revascularization Circulation, November 9, 1999; 100 (2009): II-134 - II-138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Chu, J.-q. Kuang, A. McGinn, A. Giaid, S. Korkola, and R. C. -J. Chiu ANGIOGENIC RESPONSE INDUCED BY MECHANICAL TRANSMYOCARDIAL REVASCULARIZATION J. Thorac. Cardiovasc. Surg., November 1, 1999; 118(5): 849 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. F. Chu, A. Giaid, J.-q. Kuang, A. N. McGinn, C. M. Li, M. P. Pelletier, and R. C.-J. Chiu Angiogenesis in transmyocardial revascularization: comparison of laser versus mechanical punctures Ann. Thorac. Surg., August 1, 1999; 68(2): 301 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. M. Mueller, H. T. Tevaearai, C.-Y. Genton, P. Chaubert, and L. K. von Segesser Are there vascular density gradients along myocardial laser channels? Ann. Thorac. Surg., July 1, 1999; 68(1): 125 - 129. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
