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Ann Thorac Surg 1998;65:1730-1736
© 1998 The Society of Thoracic Surgeons

Original articles: cardiovascular

Brain Damage and Myocardial Dysfunction: Protective Effects of Magnesium in the Newborn Pig

Joseph Caspi, MDa, John G. Coles, MDa, Lee N. Benson, MDb, Gregory J. Wilson, MDc

a Divisions of Cardiovascular Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada
b and Pediatric Cardiology The Hospital for Sick Children, Toronto, Ontario, Canada
c Department of Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada

Accepted for publication December 7, 1997.

Address reprint requests to Dr Caspi, Pediatric Cardiology, Children’s Hospital, 200 Henry Clay Ave, New Orleans, LA 70118

Background. Brain damage is associated with myocardial dysfunction resulting from excessive release of endogenous catecholamines and Ca2+ overload. Magnesium ion, a natural Ca2+ blocker, has recently been recognized as a myoprotective agent.

Methods. Myocardial function was assessed in 3- to 7-day-old piglets from pressure–volume data (obtained by the conductance catheter/micromanometer technique) before and for 4 hours after ligation of the aortic arch vessels and was correlated with ultrastructural changes. Group a (n = 6) received MgSO4 immediately after induction of brain damage for 4 hours, whereas group b (n = 6) did not receive MgSO4 and served as control.

Results. In both groups after induction of brain damage, there was a significant (p < 0.05) increase in end-systolic elastance and preload-recruitable stroke work that persisted for 1 hour. However, after 2 and 4 hours, there was a significant (p < 0.05) reduction in both variables in group b (end-systolic elastance, 74% ± 5% and 59% ± 6%, respectively, and preload-recruitable stroke work, 77% ± 4% and 64% ± 3%, respectively, compared with baseline), and in group a, the values returned to baseline. The chamber stiffness index rose significantly (p < 0.05) in group b 15 minutes after induction of brain damage and remained significantly (p < 0.05) higher for 4 hours versus no significant change in group a. Plasma levels of epinephrine and norepinephrine were similar in the groups before and after brain damage. Electron microscopic study showed severe ultrastructural changes in group b and significantly milder changes in group a.

Conclusions. We conclude that MgSO4 may protect the neonatal myocardium when administered immediately after brain damage.






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