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Ann Thorac Surg 1998;65:1690-1697
© 1998 The Society of Thoracic Surgeons
a Departments of Surgery, Pathology, Pharmacology and Therapeutics, and Anesthesia, The University of British Columbia, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
Accepted for publication February 3, 1998.
Address reprint requests to Dr Qayumi, Department of Surgery, Room 3100, 910 W 10th Ave, Vancouver, BC, Canada V5Z 4E3
e-mail: (qayumi {at}unixg.ubc.ca)
Background. This swine model was designed to elucidate the role of platelet-activating factor in regional myocardial ischemia-reperfusion injury.
Methods. In groups 1 and 2 (n = 12 each), the left anterior descending coronary artery was ligated for 60 minutes to induce regional myocardial ischemia followed by 6 hours of reperfusion. Group 1 received the platelet-activating factor antagonist TCV-309 before ischemia, whereas group 2 did not. Group 3 (n = 3) had a sham operation.
Results. Animals in group 2 exhibited significant (p < 0.05) hemodynamic instability and myocardial depression during the reperfusion period. Despite preventive measures, 7 of the 12 animals experienced severe dysrhythmias in the form of atrial and ventricular fibrillation leading to cardiac arrest. In contrast, animals in group 1 in whom the effects of platelet-activating factor were blocked by the specific platelet-activating factor receptor antagonist TCV-309 were hemodynamically stable and had significantly (p < 0.05) better myocardial function. This significant difference in global myocardial function between the groups was observed in the presence of similar morphologic findings and regional myocardial function.
Conclusions. These results suggest that platelet-activating factor has a definite influence on global myocardial dysfunction associated with regional myocardial ischemia-reperfusion injury.
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