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Ann Thorac Surg 1998;65:1625-1630
© 1998 The Society of Thoracic Surgeons

Original articles: cardiovascular

HeartMate Left Ventricular Assist Device as Bridge to Heart Transplantation

Bansi Koul, MD, PhDa, Jan-Otto Solem, MD, PhDa, Stig Steen, MD, PhDa, Henrik Casimir-Ahn, MD, PhDb, Hans Granfeldt, MDb, Urban J. Lönn, MDb

a Department of Thoracic and Cardiovascular Surgery, University Hospitals in Lund, Sweden
b Department of Thoracic and Cardiovascular Surgery, University Hospitals, Linköping, Sweden

Accepted for publication January 21, 1998.

Address reprint requests to Dr Koul, Department of Thoracic and Cardiovascular Surgery, University Hospital, 221 85 Lund, Sweden

Background. Because of the limited supply of donor hearts, prospective recipients continue to die while on the waiting list for heart transplantation. Use of long-term mechanical circulatory support devices as a bridge to transplantation may reduce this mortality. However, with the present state of technology, continued clinical evaluation of the various long-term, mechanical circulatory support devices available is mandatory.

Methods. Sixteen patients were bridged with the HeartMate left ventricular assist device (LVAD) to heart transplantation for New York Heart Association functional class IV cardiac failure. Twelve pneumatic and six electric devices were used. The mean cardiac index and the mean pulmonary vascular resistance of the patient cohort were 1.7 1 · min-1 · m-2 and 3.1 Wood units, respectively.

Results. The mean LVAD support time per transplanted patient was 237 days, with a cumulative LVAD support time of about 7.2 years. Bleeding was the main operative and postoperative complication. Two patients suffered from neurologic complications and there were two major incidents of device malfunction. Twelve patients (75%) now have received a transplant, 3 (19%) are awaiting a transplant, and in 1 patient (6%), the device was explanted after spontaneous left ventricular recovery. Eleven of the 12 patients who received a transplant are alive and doing well. The HeartMate LVAD gave adequate circulatory support over extended periods of time and reversed the vital organ dysfunction. Since the start of the LVAD program, only 1 patient has died on our heart transplantation waiting list, compared to nine deaths in the 2 preceding years.

Conclusions. The HeartMate LVAD bridge to heart transplantation can be performed with low post-LVAD implantation and posttransplantation mortality and offers 1- and 2-year posttransplantation actuarial survival rates comparable to those for nonbridged heart transplant recipients.




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