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Ann Thorac Surg 1998;65:1014-1019
© 1998 The Society of Thoracic Surgeons

Surgical Management of Radiation-Induced Heart Disease

^a Department of Cardiovascular and Thoracic Surgery, Rush-Presbyterian-St. Luke’s Medical Center, Chicago, Illinois, USA

Accepted for publication October 29, 1997.

Address reprint requests to Dr Goldin, Department of Cardiovascular and Thoracic Surgery, Rush-Presbyterian-St. Luke’s Medical Center, 1750 W Harrison Ave (714 Jelke S), Chicago, IL 60612

Background. With the increasing population of patients with prior mediastinal irradiation, cardiac surgeons will encounter patients with radiation-induced damage to the heart and the great vessels. Awareness of the pathology and the surgical management is essential to provide optimal care for these patients.

Methods. Eight patients with radiation-induced heart disease were encountered in the last 10 years. After a brief clinical presentation, the surgical management of radiation-induced heart disease is reviewed.

Results. Radiation can affect all the structures in the heart, including the coronary arteries, the valves, and the conduction system. The pericardium is the most commonly involved, and the conduction system is the least involved. Pericardiectomy is quite effective in patients with symptomatic pericardial effusion or constriction. The coronary lesions are located predominantly in the ostial or proximal regions of the epicardial vessels. Percutaneous transluminal coronary angioplasty alone appears to have a high rate of restenosis. Surgical revascularization has good long-term results, and the internal mammary artery should be used if it is satisfactory. The aortic and mitral valves are more commonly involved than the tricuspid and pulmonary valves. Myocardial dysfunction predominantly affects the right ventricle and requires particular attention during cardiopulmonary bypass and in the postoperative period. Restoration of sinus rhythm is essential in view of stiffness of the ventricles. Flexibility in the surgical approach with selective use of thoracotomy will facilitate the surgical procedure in certain patients.

Conclusions. Surgeons should be well versed in all the manifestations and the management of radiation-induced heart disease.

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