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Ann Thorac Surg 1998;65:868-874
© 1998 The Society of Thoracic Surgeons

Current Review

The Biology of Estrogen-Mediated Repair of Cardiovascular Injury

Craig H. Selzman, MD, Thomas A. Whitehill, MD, Brian D. Shames, MD, Edward J. Pulido, MD, Brian C. Cain, MD, Alden H. Harken, MD

Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado, USA

Dr Selzman, Department of Surgery, University of Colorado Health Sciences Center, Campus Box C-320, 4200 East Ninth Ave, Denver, CO 80262 (e-mail: selzman_c@defiance.uchsc.edu).

Women appear to be protected from cardiovascular disease until the onset of menopause. Considerable evidence supports the atheroprotective effects of endogenous and supplemental estrogens. The beneficial effects of estrogens on lipid metabolism cannot wholly explain this phenomenon. Accumulating data suggest that estrogen may act at the cellular and molecular level to influence atherogenesis. The purpose of this review is to examine lipid-independent mechanisms of estrogen-mediated atheroprotection after cardiovascular injury.




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