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Ann Thorac Surg 1998;65:691-695
© 1998 The Society of Thoracic Surgeons

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Original Articles: Cardiovascular

Platelet and Neutrophil Activation During Cardiac Surgical Procedures: Impact of Cardiopulmonary Bypass

Center for Experimental Therapeutics and Reperfusion Injury Department of Anesthesia Research Laboratories, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Department of Cardiac Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

Accepted for publication September 3, 1997.

Dr Magnani, Coagulation Research Laboratory, Department of Anesthesia Research Laboratories, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115 (e-mail: magnani@zeus.bwh.harvard.edu).

Background. Platelet and neutrophil activation plays a crucial role in reperfusion injury. To determine whether platelet and neutrophil activation occurs in the coronary circulation after cold cardioplegic arrest and reperfusion, we studied 22 patients undergoing coronary artery bypass or valve procedures, or both procedures.

Methods. Blood was sampled from the coronary sinus and the radial artery (A) before bypass; (B) immediately after cross-clamp release; and (C) 5 minutes after cross-clamp release; and was analyzed for surface markers of platelet (CD62P) and neutrophil (CD11b) activation.

Results. During bypass, platelet activation increased significantly (p < 0.01) over prebypass values, but no difference was seen between arterial and coronary sinus samples. Neutrophil activation also increased significantly (p < 0.001) during bypass, but there was no difference between arterial and coronary sinus samples.

Conclusions. Cellular activation occurs locally in the coronary circulation during bypass, but no more so after cold cardioplegic arrest and reperfusion.

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