ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Arata Murakami
Takuro Misaki
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Uozaki, Y.
Right arrow Articles by Misaki, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Uozaki, Y.
Right arrow Articles by Misaki, T.

Ann Thorac Surg 1998;65:663-666
© 1998 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Effect of Assisted Circulation on Left Ventricular Performance in a Canine Model

Yasuhiro Uozaki, MD, Arata Murakami, MD, Hidetsugu Asanoi, MD, Shinji Ishizaka, MD, Takuro Misaki, MD

First Department of Surgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan

Accepted for publication September 2, 1997.

Dr Uozaki, First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-0194, Japan.

Background. Little is known about left ventricular performance during venoarterial bypass and left heart bypass (LHB) after cross-clamping the descending thoracic aorta. We evaluated the effects of venoarterial bypass and LHB on ventricular load optimization and left ventricular work efficiency.

Methods. We used the left ventricular conductance catheter and a micromanometer in 7 anesthetized mongrel dogs. We assessed preload by the end-diastolic volume, afterload by the effective arterial elastance, and left ventricular contractile properties by the slope of the end-systolic pressure–volume relationship. In addition, optimal ventricular arterial coupling (ratio of effective arterial elastance to slope of end-systolic pressure–volume relationship) and left ventricular work efficiency (ratio of external work to pressure–volume area) were calculated.

Results. The decrease in preload was much greater with LHB than venoarterial bypass. There were no significant differences in afterload and left ventricular contractility between venoarterial bypass and LHB. The ventricular arterial coupling during LHB was near 0.50 (0.69 ± 0.16) in the "best heart" condition (effective arterial elastance = slope of end-systolic pressure–volume relationship/2), whereas the work efficiency during LHB was at maximum (0.73 ± 0.12).

Conclusions. We conclude that LHB has a more beneficial effect on left ventricular performance after cross-clamping of the descending thoracic aorta.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1998 by The Society of Thoracic Surgeons.