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Ann Thorac Surg 1998;65:397-402
© 1998 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Preoperative Assessment of Coronary Artery Disease in Aortic Stenosis: A Dipyridamole Echocardiographic Study

Stefano Maffei, MD, Monica Baroni, MD, Marco Terrazzi, MD, Fabrizio Paoli, MD, Paolo Ferrazzi, MD, Andrea Biagini, MD

CNR Institute of Clinical Physiology, Pisa, Italy

Accepted for publication July 26, 1997.

Dr Maffei, Ospedale Pediatrico Apuano, Via Aurelia sud, Montignoso, 54100, Massa, Italy.

Background. The aim of this study was to establish the feasibility, safety, and diagnostic accuracy of the dipyridamole echocardiography test in patients with severe aortic valve stenosis for noninvasive detection of coexisting coronary artery disease.

Methods. The high-dose dipyridamole echocardiography test was performed in 52 patients with severe aortic stenosis; all patients also underwent coronary angiography, independent of test results, before cardiac operation.

Results. The dipyridamole echocardiography test was completed without major complications. One patient had transient atrial fibrillation that was reversed by aminophylline. Thirty-one patients (60%) had a negative test result; all had normal coronary arteries. Ten of the 21 patients (48%) with a positive test result had coexisting coronary artery disease. The positive predictive value of the dipyridamole echocardiography test for detection of coronary disease in patients with severe aortic stenosis was 48%. The negative predictive value was 100%. The sensitivity was 100% and the specificity was 74%.

Conclusions. Dipyridamole echocardiography is a safe and feasible tool in patients with severe aortic stenosis eligible for a cardiac operation. A negative test result reliably rules out a significant stenosis, whereas a positive one is much less accurate in predicting coronary artery disease.




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R. M. Fleming and L. D. Boyd
High-Dose Dipyridamole and Gated Sestamibi SPECT Imaging Provide Diagnostic Resting and Stress Ejection Fractions Useful for Predicting Extent of Coronary Artery Disease
Angiology, July 1, 2002; 53(4): 415 - 421.
[Abstract] [PDF]

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 ANGIOLOGYHome page
R. M. Fleming
A Tete-a-Tete Comparison of Ejection Fraction and Regional Wall Motion Abnormalities as Measured by Echocardiography and Gated Sestamibi SPECT
Angiology, May 1, 2002; 53(3): 313 - 321.
[Abstract] [PDF]


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