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Ann Thorac Surg 1998;65:88-94
© 1998 The Society of Thoracic Surgeons

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Original Articles: Cardiovascular

The Role of Gender in Heart Transplantation

Section of Cardiac and Thoracic Surgery, Temple University Health Sciences Center, Philadelphia, Pennsylvania, USA
Division of Cardiothoracic Surgery, Kansas University Medical Center, Kansas City, Kansas, USA

Accepted for publication June 30, 1997.

Dr Prendergast, Division of Cardiothoracic Surgery, Kansas University Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160.

Presented at the Sixteenth Annual Meeting of the International Society for Heart and Lung Transplantation, New York, NY, March 15–18, 1996.

Background. The effect of donor and recipient gender on the outcome of heart transplantation (HT) remains uncertain.

Methods. One hundred seventy-four patients who underwent HT were divided into four groups according to donor and recipient gender. Group A consisted of 81 men who received male donor hearts, group B of 18 women who received female donor hearts, group C of 21 women who received male donor hearts, and group D of 54 men who received female donor hearts. All patients were treated by the same group of surgeons according to standard HT protocols. Comparisons were made between groups with regard to short- and long-term outcomes.

Results. Donor gender and recipient gender did not affect outcomes significantly. Overall, donor-recipient gender mismatching significantly increased the number of rejection episodes and reduced creatinine clearance, survival, and censored survival in the first year after HT (p < 0.05). More specifically, among female recipients, donor-recipient gender mismatching significantly increased the number of rejection episodes and decreased creatinine clearance in the first year after HT (p < 0.05); among male recipients, donor-recipient gender mismatching significantly reduced 1-year survival and censored survival to date after HT (p < 0.05).

Conclusions. Donor-recipient gender matching plays a significant role in determining HT outcomes.

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