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Yoshiki Sawa
Toshiki Takahashi
Hajime Ichikawa
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Ann Thorac Surg 1998;65:54-58
© 1998 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Early Detection of Cardiac Damage With Heart Fatty Acid-Binding Protein After Cardiac Operations

Ken Suzuki, MD, Yoshiki Sawa, MD, Keishi Kadoba, MD, Toshiki Takahashi, MD, Hajime Ichikawa, MD, Koji Kagisaki, MD, Toshihiro Ohata, MD, Hikaru Matsuda, MD

First Department of Surgery, Osaka University, Osaka, Japan

Accepted for publication October 3, 1997.

Dr Suzuki, First Department of Surgery, Osaka University Medical School, 2-2 Yamada-Oka, Suita, Osaka, 565, Japan.

Background. It is still difficult to evaluate myocardial damage in the acute phase of reperfusion in cardiac operations. We investigated the clinical significance of human heart fatty acid-binding protein (HH-FABP) for detecting myocardial damage after cardiac operations earlier than creatine kinase MB isoform or troponin-T.

Methods. Blood samples from 20 patients who underwent coronary artery bypass grafting were collected serially after reperfusion to measure serum levels of creatine kinase-MB, troponin-T, and HH-FABP.

Results. Serum HH-FABP levels peaked earliest after reperfusion. In addition, the maximum serum HH-FABP level was predictable immediately after reperfusion. The maximum serum HH-FABP level correlated with the maximum serum creatine kinase-MB or troponin-T level, as well as with the aortic cross-clamp time or the maximum dose of catecholamines administered after reperfusion.

Conclusions. Measurements of HH-FABP allow for earlier evaluation of myocardial damage in the acute phase of reperfusion. Human heart fatty acid-binding protein may be a useful indicator of myocardial damage after cardiac operations.




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