HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Yukio Chiba Ryusuke Muraoka Akio Ihaya Katsuhiko Matsuyama Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chiba, Y. Articles by Matsuyama, K. Search for Related Content PubMed PubMed Citation Articles by Chiba, Y. Articles by Matsuyama, K.

Ann Thorac Surg 1998;65:107-113
© 1998 The Society of Thoracic Surgeons

---

Original Articles: Cardiovascular

Effects of Depletion of Leukocytes and Platelets on Cardiac Dysfunction After Cardiopulmonary Bypass

The Second Department of Surgery, Fukui Medical School, Fukui, Japan

Accepted for publication July 7, 1997.

Dr Chiba, The Second Department of Surgery, Fukui Medical School, 23-3 Shimoaizuki, Matsuoka-cho, Yoshida-gun, Fukui-ken, 910-11 Japan.

Background. This study examined the effects of the depletion of leukocytes and platelets from circulated blood on cardiac function after cardiopulmonary bypass in 37 patients who underwent coronary artery bypass grafting or aortic valve replacement.

Methods. Leukocytes and platelets were removed continuously using a blood cell separator, beginning immediately after the start of the operation and ending 1 hour after the release of the aortic cross-clamp in 19 patients (LPD group), but not in the remaining 18 patients (control group). Blood cell counts and levels of thromboxane B₂, 6-keto-prostaglandin F₁, leukocyte elastase, complements C3a and C4a, thrombin-antithrombin III complex, and D-dimer were determined periodically during and after the operation. The cardiac index, the difference between the central and peripheral core temperatures, and the doses of catecholamines and vasodilators required to support the circulation in the early postoperative period also were assessed.

Results. Leukocyte and platelet counts and levels of leukocyte elastase, thromboxane B₂, thromboxane₂/6-keto- prostaglandin F₁, thrombin-antithrombin III complex, and D-dimer were significantly lower in the LPD group than in the control group before and after the release of the aortic cross-clamp and during the perioperative period. There were no significant differences in the levels of 6-keto-prostaglandin F₁ or complements C3a and C4a between the two groups. The catecholamine dose was significantly lower in the LPD group than in the control group (1.1 ± 2.5 versus 5.0 ± 5.2 mg/kg, respectively). Fewer patients required the use of nitroprusside as a vasodilator in the LPD group than in the control group (1/19 versus 12/18, respectively).

Conclusions. The depletion of leukocytes and platelets using a blood cell separator prevents the deterioration of cardiac function after cardiac operations using cardiopulmonary bypass.

This article has been cited by other articles:

				J. W. Hammon Extracorporeal Circulation: The Response of Humoral and Cellular Elements of Blood to Extracorporeal Circulation Card. Surg. Adult, January 1, 2008; 3(2008): 370 - 389. [Full Text]

				R. Gerrah, A. Brill, S. Tshori, A. Lubetsky, G. Merin, and D. Varon Using Cone and Plate(let) Analyzer to Predict Bleeding in Cardiac Surgery. Asian Cardiovasc Thorac Ann, August 1, 2006; 14(4): 310 - 315. [Abstract] [Full Text] [PDF]

				G. M. Palatianos, G. Balentine, E. G. Papadakis, C. D. Triantafillou, M. I. Vassili, A. Lidoriki, A. Dinopoulos, and G. M. Astras Neutrophil depletion reduces myocardial reperfusion morbidity Ann. Thorac. Surg., March 1, 2004; 77(3): 956 - 961. [Abstract] [Full Text] [PDF]

				B. S. Allen, M. Castella, G. D. Buckberg, and Z. Tan Conditioned blood reperfusion markedly enhances neurologic recovery after prolonged cerebral ischemia J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1851 - 1858. [Abstract] [Full Text] [PDF]

				A. J. Chong, C. R. Hampton, and E. D. Verrier Microvascular Inflammatory Response in Cardiac Surgery Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2003; 7(3): 333 - 354. [Abstract] [PDF]

				P. Menasche and L. H. Edmunds Jr. Extracorporeal Circulation: The Inflammatory Response Card. Surg. Adult, January 1, 2003; 2(2003): 349 - 360. [Full Text]

				D. Paparella, T. M. Yau, and E. Young Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update Eur J Cardiothorac Surg, February 1, 2002; 21(2): 232 - 244. [Abstract] [Full Text] [PDF]

				G. E. Hill The Inflammatory Response to Cardiopulmonary Bypass-- Should It Be Treated? Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2001; 5(3): 229 - 235. [Abstract] [PDF]

				B. S Allen and M. N Ilbawi Hypoxia, reoxygenation and the role of systemic leukodepletion in pediatric heart surgery Perfusion, January 1, 2001; 16(1_suppl): 19 - 29. [Abstract] [PDF]

				S. Massberg, M. Sausbier, P. Klatt, M. Bauer, A. Pfeifer, W. Siess, R. Fassler, P. Ruth, F. Krombach, and F. Hofmann Increased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3',5'-Monophosphate Kinase I J. Exp. Med., April 19, 1999; 189(8): 1255 - 1264. [Abstract] [Full Text] [PDF]