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Ann Thorac Surg 1997;64:1827-1829
© 1997 The Society of Thoracic Surgeons

Case Report

Intraoperative Discovery of Neuroblastoma in an Infant With Pulmonary Atresia

Doff B. McElhinney, MS, V. Mohan Reddy, MD, Burt G. Feuerstein, MD, PhD, Gerald R. Marx, MD, Frank L. Hanley, MD

Division of Cardiothoracic Surgery and Departments of Laboratory Medicine and Neurosurgery, University of California, San Francisco, San Francisco, California

Accepted for publication July 26, 1997.

There have been 28 previously reported cases of neuroblastoma associated with congenital heart disease. Because many of these have been defects of the conotruncal region, it has been proposed that abnormal neural crest cell migration or maturation may be a factor that links these normally disparate pathologic conditions. Most neuroblastomas in these cases have been detected at autopsy or by radiologic studies conducted in the evaluation of the cardiac anomalies. Recently, we discovered an occult posterior mediastinal neuroblastoma in a patient undergoing a unifocalization procedure for tetralogy of Fallot with pulmonary atresia and major aortopulmonary collaterals. The tumor was resected, and the patient has demonstrated no evidence of residual or metastatic neuroblastoma.




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Home page
 Arch. Dis. Child.Home page
R Holzer and R C G Franklin
Congenital heart disease and neuroblastoma: just coincidence?
Arch. Dis. Child., July 1, 2002; 87(1): 61 - 64.
[Abstract] [Full Text] [PDF]


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