ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Robert R. Waterford
Joseph R. Van Camp
Steven F. Bolling
Louis A. Brunsting, III
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Waterford, R. R.
Right arrow Articles by Brunsting, L. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Waterford, R. R.
Right arrow Articles by Brunsting, L. A., III

Ann Thorac Surg 1997;64:1682-1685
© 1997 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Adjustable Model of Chronic Left Ventricular Dysfunction

Robert R. Waterford, MD, Joseph R. Van Camp, MD, Marsha A. Gallagher, Michael T. Anderson, Steven F. Bolling, MD, Louis A. Brunsting, III, MD

Section of Thoracic Surgery, The University of Michigan Medical Center, Ann Arbor, Michigan

Accepted for publication May 16, 1997.

Background. As an adjunct to the development of skeletal muscle-powered left ventricular assist devices, an adjustable model of chronic left ventricular failure was developed.

Methods. Implantation of a left ventricular balloon to induce heart failure was accomplished via left thoracotomy. Upon recovery, left ventricular failure was simulated by manipulation of left ventricular balloon volume to chronically raise left atrial pressure.

Results. Left atrial pressure increased from a baseline of 9.3 ± 0.7 mm Hg to 18.5 ± 1.2 mm Hg, 20.2 ± 1.8 mm Hg, and 26.0 ± 1.2 mm Hg by the 2nd, 6th, and 10th postoperative week, respectively. Cardiac index declined from a baseline of 4.4 ± 0.3 L • min-1 • m-2, reaching stability by the 8th postoperative week at 3.0 ± 0.4 L • min-1 • m-2. Stroke volume index declined from 1.12 ± 0.1 mL • kg-1 • beat-1 to 0.60 ± 0.1 mL • kg-1 • beat-1 by the 10th postoperative week. Mean survival was 75 ± 7 days. Causes of death included left ventricular failure, thromboembolism, and euthanasia.

Conclusions. This method of simulating chronic left ventricular dysfunction proved to be stable and adjustable and has been useful in the development of ventricular assist systems.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1997 by The Society of Thoracic Surgeons.