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Adnan Cobanoglu
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Ann Thorac Surg 1997;64:1461-1464
© 1997 The Society of Thoracic Surgeons

Case Report

FK506-Induced Fulminant Leukoencephalopathy After Single-Lung Transplantation

Ganeshakrishnan K. Thyagarajan, MD, Adnan Cobanoglu, MD, Wendy Johnston, MD

Division of Cardiopulmonary Surgery and Department of Neurology, Oregon Health Sciences University, Portland, Oregon

Accepted for publication June 14, 1997.

FK506 is being used increasingly to prevent rejection after organ transplantation. Its use is associated with a wide spectrum of neurotoxicity, which has been described after most solid organ transplantations, but reports after lung transplantation are extremely rare. This is a report of the pathologic correlation of the clinical and radiologic features of delayed FK506-induced fulminant leukoencephalopathy after single-lung transplantation. The patient presented with neurologic symptoms that progressed to seizure activity. Neuroimaging showed diffuse changes in the brain, and results of a brain biopsy were consistent with leukoencephalopathy with microglial and astrocytic activation. The patient had a remarkable improvement in clinical status after discontinuation of FK506 administration, with resolution of the changes seen on neuroimaging.




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