ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Alain Bernard
Denis Caillot
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bernard, A.
Right arrow Articles by Favre, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bernard, A.
Right arrow Articles by Favre, J. P.

Ann Thorac Surg 1997;64:1441-1447
© 1997 The Society of Thoracic Surgeons

Original Articles: General Thoracic

Surgical Management of Invasive Pulmonary Aspergillosis in Neutropenic Patients

Alain Bernard, MD, Denis Caillot, MD, Jean François Couaillier, MD, Olivier Casasnovas, MD, Henri Guy, MD, Jean Pierre Favre, MD

Departments of Surgery, Clinical Hematology, and Radiology, University of Burgundy, Dijon, France

Accepted for publication May 21, 1997.

Background. The aim of our study was to clarify the indications for operation in invasive pulmonary aspergillosis.

Methods. Nineteen patients with hematologic malignancy, in whom invasive pulmonary aspergillosis developed during the course of neutropenia, had operations. Neutropenia lasted 28 days (range, 15 to 45 days). The preoperative diagnosis of invasive pulmonary aspergillosis was based on computed tomographic scan findings (halo or air crescent signs).

Results. Eight patients underwent emergency operations, before marrow recovery, for prevention of massive hemoptysis. The criterion for operation was an aspergillosis lesion that contacted the pulmonary artery on computed tomography. A lobectomy was performed in all cases. A sleeve resection of the pulmonary artery was necessary on two occasions. There was one postoperative death due to extensive aspergillosis. The length of hospitalization after operation was 13 days (range, 6 to 18 days). Seven patients were treated by elective resection of a residual mass (before hematologic therapy in 6 cases). The types of resection performed were lobectomy (n = 4), lingulectomy (n = 1), and wedge resection (n = 2). There were no postoperative deaths. The average length of stay before discharge from the hospital was 11 days (range, 7 to 20 days). The surgical resection was performed as a diagnostic procedure in the 4 remaining patients after an allotted time of 14 days (range, 4 to 24 days) from initiation of antifungal therapy.

Conclusions. The combination of antifungal agents and surgical resection is an efficient strategy for the treatment of invasive pulmonary aspergillosis in patients with hematologic malignancy.




This article has been cited by other articles:


Home page
 ICVTSHome page
B. C. Danner, V. Didilis, H. Dorge, D. Mikroulis, G. Bougioukas, and F. A. Schondube
Surgical treatment of pulmonary aspergillosis/mycosis in immunocompromised patients
Interactive CardioVascular and Thoracic Surgery, October 1, 2008; 7(5): 771 - 776.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Bulpa, A. Dive, and Y. Sibille
Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease
Eur. Respir. J., October 1, 2007; 30(4): 782 - 800.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
N. Singh and D. L. Paterson
Aspergillus Infections in Transplant Recipients
Clin. Microbiol. Rev., January 1, 2005; 18(1): 44 - 69.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. O. Soubani and P. H. Chandrasekar
The Clinical Spectrum of Pulmonary Aspergillosis*
Chest, June 1, 2002; 121(6): 1988 - 1999.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
D. Gossot, P. Validire, R. Vaillancourt, G. Socie, H. Esperou, A. Devergie, P. Guardiola, D. Grunenwald, E. Gluckman, and P. Ribaud
Full thoracoscopic approach for surgical management of invasive pulmonary aspergillosis
Ann. Thorac. Surg., January 1, 2002; 73(1): 240 - 244.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. Caillot, J.-F. Couaillier, A. Bernard, O. Casasnovas, D. W. Denning, L. Mannone, J. Lopez, G. Couillault, F. Piard, O. Vagner, et al.
Increasing Volume and Changing Characteristics of Invasive Pulmonary Aspergillosis on Sequential Thoracic Computed Tomography Scans in Patients With Neutropenia
J. Clin. Oncol., January 1, 2001; 19(1): 253 - 259.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
K. Meijer, W. E. de Graaff, S. M. G. J. Daenen, and J. van der Meer
Successful Treatment of Massive Hemoptysis in Acute Leukemia With Recombinant Factor VIIa
Arch Intern Med, July 24, 2000; 160(14): 2216 - 2217.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J.-F. Regnard, P. Icard, M. Nicolosi, L. Spagiarri, P. Magdeleinat, B. Jauffret, and P. Levasseur
Aspergilloma: a series of 89 surgical cases
Ann. Thorac. Surg., March 1, 2000; 69(3): 898 - 903.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
J.-P. Latge
Aspergillus fumigatus and Aspergillosis
Clin. Microbiol. Rev., April 1, 1999; 12(2): 310 - 350.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1997 by The Society of Thoracic Surgeons.