ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Robert C. King
Curtis G. Tribble
Irving L. Kron
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by King, R. C.
Right arrow Articles by Kron, I. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by King, R. C.
Right arrow Articles by Kron, I. L.
Related Collections
Right arrowRelated Article

Ann Thorac Surg 1997;64:795-800
© 1997 The Society of Thoracic Surgeons

Original Article: General Thoracic

Acellular Low-Potassium Dextran Preserves Pulmonary Function After 48 Hours of Ischemia

Robert C. King, MD, Oliver A. R. Binns, MD, R. Chai Kanithanon, BA, Patrick E. Parrino, MD, T. Brett Reece, BA, James D. Maliszewskyj, RN, Kimberly S. Shockey, MS, Curtis G. Tribble, MD, Irving L. Kron, MD

Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia

Background. We previously have shown that extracellular preservation solutions provide superior pulmonary protection after 18 hours of cold ischemia at 4°C in an isolated, whole-blood–perfused, rabbit lung model. We also reported that the addition of 20% whole blood to a low-potassium dextran solution (BLPD) conferred no discernible advantage over low-potassium dextran (LPD) alone in this same model. Our current study was aimed at documenting the importance of blood in buffering extracellular preservation solutions during 24 to 48 hours of hypothermic ischemia.

Methods. We studied three groups of lungs using an isolated, whole-blood–perfused, ventilated, rabbit lung model. Lungs were flushed with Euro-Collins, LPD, or BLPD solution, and then were reperfused after 24, 36, or 48 hours of hypothermic storage at 4°C. Continuous measurements of pulmonary artery pressure, pulmonary vascular resistance, left atrial pressure, tidal volume, and dynamic airway compliance were obtained. Fresh, non-recirculated venous blood was used to determine single-pass pulmonary venous-to-arterial O2 gradients.

Results. The 24-hour Euro-Collins group could not be completed because of immediate reperfusion failure. The 36-hour LPD group oxygenated significantly better than the 36-hour BLPD group (363.3 ± 65.1 versus 145.3 ± 40.3 mm Hg, respectively; p = 0.015). The 48-hour LPD group also experienced significant improvements in oxygenation when compared with the 48-hour BLPD group (pulmonary venous-arterial O2 difference of 239.4 ± 48.4 versus 70.7 ± 19.5 mm Hg, respectively; p = 0.012). The 48-hour LPD group also displayed significant improvements in pulmonary artery pressure (34.72 ± 0.96 versus 55.52 ± 7.37 mm Hg, respectively; p = 0.031) and pulmonary vascular resistance (39,737 ± 1,291 versus 67,594 ± 9,467 dynes • s • cm-5, respectively; p = 0.027) when compared with the 48-hour BLPD group. There were no significant differences between the three LPD groups.

Conclusions. Extracellular solutions provide improved pulmonary preservation in an isolated rabbit lung model after 48 hours of cold ischemia. The addition of blood to extracellular preservation solutions diminishes pulmonary function when combined with ischemic periods of 36 to 48 hours.


Related Article

Discussion
Ann. Thorac. Surg. 1997 64: 800. [Extract] [Full Text]



This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
F. R. Rega, A. P. Neyrinck, G. M. Verleden, T. E. Lerut, and D. E. M. Van Raemdonck
How long can we preserve the pulmonary graft inside the nonheart-beating donor?
Ann. Thorac. Surg., February 1, 2004; 77(2): 438 - 444.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
R. Aguilo, E. Serra, B. Togores, A. de la Pena, C. Santos, and A. G. N. Agusti
Long-term (72 hours) preservation of rat lungs
J. Thorac. Cardiovasc. Surg., April 1, 2003; 125(4): 907 - 912.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. M. Aziz, T. M. Pillay, P. A. Corris, J. Forty, C. J. Hilton, A. Hasan, and J. H. Dark
Perfadex for clinical lung procurement: is it an advance?
Ann. Thorac. Surg., March 1, 2003; 75(3): 990 - 995.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. de Perrot, M. Liu, T. K. Waddell, and S. Keshavjee
Ischemia-Reperfusion-induced Lung Injury
Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 490 - 511.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. THABUT, I. VINATIER, O. BRUGIERE, G. LESECHE, P. LOIRAT, A. BISSON, J. MARTY, M. FOURNIER, and H. MAL
Influence of Preservation Solution on Early Graft Failure in Clinical Lung Transplantation
Am. J. Respir. Crit. Care Med., October 1, 2001; 164(7): 1204 - 1208.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
O. D. SCHNEUWLY, M. LICKER, C. M. PASTOR, A. SCHWEIZER, D. O. SLOSMAN, Y. KAPANCI, L. P. NICOD, J. ROBERT, A. SPILIOPOULOS, and D. R. MOREL
Beneficial Effects of Leukocyte-depleted Blood and Low-potassium Dextran Solutions on Microvascular Permeability in Preserved Porcine Lung
Am. J. Respir. Crit. Care Med., August 1, 1999; 160(2): 689 - 697.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1997 by The Society of Thoracic Surgeons.