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Ann Thorac Surg 1997;63:459-464
© 1997 The Society of Thoracic Surgeons

Original Article: Cardiovascular

Beneficial Effects of Fluosol–Polyethylene Glycol Cardioplegia on Cold, Preserved Rabbit Heart

Joginder N. Bhayana, MD, Zhong T. Tan, MD, PhD, Jacob Bergsland, MD, Daya Balu, MD, Jaswant K. Singh, MD, Eddie L. Hoover, MD

Departments of Surgery and Pathology, State University of New York at Buffalo and Buffalo General Hospital, Buffalo, and Department of Veterans Affairs, Samuel S. Stratton Medical Center, Albany, New York

Accepted for publication September 9, 1996.

Background. Because of its high oxygen-carrying capacity, especially at low temperatures, fluosol may enhance heart preservation.

Methods. Hearts of male New Zealand white rabbits (1.5–2.0 kg) were excised and flushed through the aorta with 0°C St. Thomas' Hospital solution, fluosol, or polyethylene glycol or fluosol–polyethylene glycol cardioplegic solution. Hearts were then stored for 12 hours at 0°C and reperfused with Krebs-Henseleit buffer at 36.5°C for 60 minutes using a Langendorff system.

Results. Myocardial contractile function was significantly greater in the fluosol–polyethylene glycol cardioplegia–preserved group (p < 0.01) and polyethylene glycol–cardioplegia preserved group (p < 0.05) than in the St. Thomas' Hospital solution–preserved group. The myocardial high-energy phosphate content was significantly higher in the fluosol–polyethylene glycol–cardioplegia–preserved group (p < 0.01), with reduced release of lactate dehydrogenase (p < 0.01) in comparison with the St. Thomas' Hospital solution–preserved group.

Conclusions. The addition of fluosol and polyethylene glycol to the cardioplegic solution may enhance long-term cold heart preservation.




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