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Albertus M. Scheule
Michael J. Jurmann
Friedrich S. Eckstein
Gerhard Ziemer
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Ann Thorac Surg 1997;63:242-244
© 1997 The Society of Thoracic Surgeons

Case Report

Anaphylactic Shock After Aprotinin Reexposure: Time Course of Aprotinin-Specific Antibodies

Albertus M. Scheule, MD, Michael J. Jurmann, MD, Hans P. Wendel, PhD, Leo Häberle, MD, Friedrich S. Eckstein, MD, Gerhard Ziemer, MD

Division of Thoracic, Cardiac, and Vascular Surgery, Department of Surgery, and Department of Anesthesiology, Eberhard-Karls-University, Tuebingen, Germany

Accepted for publication August 7, 1996.

We report a case of severe anaphylactic shock during a cardiac operation that occurred as a consequence of aprotinin readministration in the presence of preformed aprotinin-specific antibodies. Both immunoglobulin G (3 hours) and immunoglobulin E (5 minutes) antibody levels dropped early after the clinical event. Despite their possibly limited clinical significance, we still recommend the conductance of specific antibody screening tests before readministration of aprotinin.




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