ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Hani Shennib
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Serrick, C.
Right arrow Articles by Shennib, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Serrick, C.
Right arrow Articles by Shennib, H.

Ann Thorac Surg 1997;63:202-208
© 1997 The Society of Thoracic Surgeons

Original Articles: General Thoracic

Prolonged Ischemia Is Associated With More Pronounced Rejection in the Lung Allograft

Cyril Serrick, MSc, Adel Giaid, PhD, Alex Reis, MD, Hani Shennib, MD

The Montreal Lung Transplant Program, Montreal, Quebec, Canada

Accepted for publication August 6, 1996.

Background. Previously it was found that ischemia-reperfusion injury in a left lung autotransplantation model could be a minor inducer of major histocompatibility complex (MHC) class II antigen expression. Thus, we hypothesized that prolonged ischemic times may result in increased expression of MHC class II antigens and predispose the lungs to the development of acute rejection early after transplantation.

Methods. Twenty conditioned dogs underwent single left lung allotransplantation. Donor lungs were subjected to 4 or 24 hours (n = 10 each) of cold ischemia. Open lung biopsies, bronchoalveolar lavage fluid, and blood samples were taken preoperatively and at various intervals up to 1 week after transplantation. Lung biopsy specimens were examined histologically for MHC class II expression and graded for acute rejection. Bronchoalveolar lavage fluid and plasma were analyzed for cytokines interleukin-2 and interferon-{gamma}.

Results. In the 4-hour ischemia group, there was mild diffuse staining of the bronchial epithelium and cellular infiltrate for MHC class II antigens after 1 week with subsequent grade 1-2 rejection. In the 24-hour ischemia group, MHC expression after 1 week revealed strong diffuse staining of bronchial epithelium, vascular endothelium, and cellular infiltrates with a significantly higher grade of rejection. Interleukin-2 and interferon-{gamma} significantly increased in BAL fluid early after transplantation in both groups.

Conclusions. Ischemic injury may predispose the lung allograft to the development of acute rejection, in part, through the upregulation of MHC class II antigen expression and the local release of cytokines.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
A. S. McCourtie, A. S. Farivar, S. M. Woolley, H. E. Merry, P. S. Wolf, B. Mackinnon-Patterson, J. C. Keech, E. FitzSullivan, and M. S. Mulligan
Alveolar Macrophage Secretory Products Effect Type 2 Pneumocytes Undergoing Hypoxia-Reoxygenation
Ann. Thorac. Surg., December 1, 2008; 86(6): 1774 - 1779.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. L. Molitor-Dart, J. Andrassy, J. Kwun, H. A. Kayaoglu, D. A. Roenneburg, L. D. Haynes, J. R. Torrealba, J. L. Bobadilla, H. W. Sollinger, S. J. Knechtle, et al.
Developmental Exposure to Noninherited Maternal Antigens Induces CD4+ T Regulatory Cells: Relevance to Mechanism of Heart Allograft Tolerance
J. Immunol., November 15, 2007; 179(10): 6749 - 6761.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Stovold, I. A. Forrest, P. A. Corris, D. M. Murphy, J. A. Smith, S. Decalmer, G. E. Johnson, J. H. Dark, J. P. Pearson, and C. Ward
Pepsin, a Biomarker of Gastric Aspiration in Lung Allografts: A Putative Association with Rejection
Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1298 - 1303.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Goto, A. Ishizaka, F. Kobayashi, M. Kohno, M. Sawafuji, S. Tasaka, E. Ikeda, Y. Okada, I. Maruyama, and K. Kobayashi
Importance of Tumor Necrosis Factor-{alpha} Cleavage Process in Post-Transplantation Lung Injury in Rats
Am. J. Respir. Crit. Care Med., December 1, 2004; 170(11): 1239 - 1246.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
A. Pereszlenyi, G. Lang, H. Steltzer, H. Hetz, A. Kocher, P. Neuhauser, W. Wisser, and W. Klepetko
Bilateral lung transplantation with intra- and postoperatively prolonged ECMO support in patients with pulmonary hypertension
Eur. J. Cardiothorac. Surg., May 1, 2002; 21(5): 858 - 863.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. M. Fiser, C. G. Tribble, S. M. Long, A. K. Kaza, J. A. Kern, D. R. Jones, M. K. Robbins, and I. L. Kron
Ischemia-reperfusion injury after lung transplantation increases risk of late bronchiolitis obliterans syndrome
Ann. Thorac. Surg., April 1, 2002; 73(4): 1041 - 1048.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
K. C. Mange, W. S. Cherikh, J. Maghirang, and R. D. Bloom
A Comparison of the Survival of Shipped and Locally Transplanted Cadaveric Renal Allografts
N. Engl. J. Med., October 25, 2001; 345(17): 1237 - 1242.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J.-M. CHARPIN, M. STERN, D. GRENET, and D. ISRAËL-BIET
Insulinlike Growth Factor-1 in Lung Transplants with Obliterative Bronchiolitis
Am. J. Respir. Crit. Care Med., June 1, 2000; 161(6): 1991 - 1998.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1997 by The Society of Thoracic Surgeons.