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Ann Thorac Surg 1996;62:1926-1934
© 1996 The Society of Thoracic Surgeons

Supplement on Bleeding and Transfusion

Extracorporeal Circulation, Hemocompatibility, and Biomaterials

Gérard Janvier, MD, PhD, Charles Baquey, PhD, Christian Roth, MD, Nathalie Benillan, MD, Sylvain Bélisle, MD, Jean-François Hardy, MD

Biomaterial Research Unit (INSERM U.306) and Department of Anesthesia, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France, and Department of Anesthesia, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada

Abstract

Background. Performance of a majority of cardiac surgical procedures requires the use of extracorporeal circulation. Contact of the patients' blood with the nonendothelial surface of the cardiopulmonary bypass circuit is responsible for several, potentially harmful systemic reactions.

Methods. The patients' response to extracorporeal circulation is reviewed briefly. The interactions between patient and circuit are discussed not only as they relate to blood-material contact, but also from a mechanical and rheologic standpoint. The theoretic benefits of the newer, more hemocompatible materials are presented, along with a review of published clinical experience with heparinized cardiopulmonary bypass circuits.

Results. The response to extracorporeal circulation extends far beyond a simple derangement of hemostasis. This inflammatory response is strongly influenced by the rheologic design of the circuit and by the physical and chemical properties of the surface. Heparinized circuits decrease inflammation, but the clinical benefits of this reduction remain unclear, except for extended cardiopulmonary support. The safe use of these circuits requires full heparinization and does not reduce allogeneic transfusions.

Conclusions. Clinicians are still in the search of the ideal material and the ideal extracorporeal circuit design. Newer, heparinized materials offer real but limited clinical benefits.




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