ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ikeda, Y.
Right arrow Articles by Kitajima, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ikeda, Y.
Right arrow Articles by Kitajima, M.

Ann Thorac Surg 1996;62:835-838
© 1996 The Society of Thoracic Surgeons

Original Articles: General Thoracic

Meanings of c-erbB and int-2 Amplification in Superficial Esophageal Squamous Cell Carcinomas

Yoshifumi Ikeda, MD, Soji Ozawa, MD, Nobutoshi Ando, MD, Yuhkoh Kitagawa, MD, Masakazu Ueda, MD, Masaki Kitajima, MD

Department of Surgery, Keio University School of Medicine, Tokyo, Japan

Accepted for publication April 22, 1996.

Background. Accumulation of genetic abnormalities is linked to the development and progression of cancer. We therefore analyzed the correlation between the clinical characteristics of superficial esophageal squamous cell carcinoma patients and oncogene amplifications.

Methods. Between 1980 and 1991, there were 63 cases of superficial esophageal carcinoma (Tis and T1 cancer) at Keio University Hospital. The T1 cases were divided into two groups: T1a cases, in which the tumor had invaded the lamina propria, and T1b cases, in which the tumor had invaded the submucosa. DNA was isolated from paraffin-embedded blocks. Oncogene amplification was determined by slot-blot hybridization.

Results. Amplification of int-2 and c-erbB was detected in 14 and 5, respectively, of the 54 cases. Three of 12 T1b patients with int-2 amplification died of distant organ metastasis. The survival rate for the group with int-2 amplification was significantly lower than that without int-2 amplification. All 4 T1b patients with c-erbB amplification had lymph node metastasis at operation.

Conclusions. These findings mean that genetic abnormalities are a useful marker for treating patients with superficial esophageal squamous cell carcinomas.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
T. Ueno, A. Tangoku, S. Yoshino, T. Abe, H. Hayashi, H. Toshimitsu, K. Hashimoto, T. Satoh, A. Oga, T. Furuya, et al.
Prediction of Nodal Metastasis by Comparative Genomic Hybridization in Biopsy Specimens from Patients with Superficial Esophageal Squamous Cell Carcinoma
Clin. Cancer Res., November 1, 2003; 9(14): 5137 - 5141.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Ueno, A. Tangoku, S. Yoshino, T. Abe, H. Toshimitsu, T. Furuya, S. Kawauchi, A. Oga, M. Oka, and K. Sasaki
Gain of 5p15 Detected by Comparative Genomic Hybridization as an Independent Marker of Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma
Clin. Cancer Res., February 1, 2002; 8(2): 526 - 533.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1996 by The Society of Thoracic Surgeons.