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Ann Thorac Surg 1996;62:654-660
© 1996 The Society of Thoracic Surgeons
Division of Cardiovascular Surgery, Department of Clinical Biochemistry, and The Centre for Cardiovascular Research, The Toronto Hospital-General Division, University of Toronto, Toronto, Ontario, Canada
Background. Transplantation of cultured cardiomyocytes into myocardial scar tissue may prevent heart failure.
Methods. Scar tissue was produced in the left ventricular free wall of 15 rats (weight, 450 g) by cryoinjury. Seven animals had operation only and survived for 8 weeks (sham group). Four weeks after cryoinjury, cultured fetal rat cardiomyocytes or culture medium was injected into the scar tissue of transplantation (n = 5) and control (n = 5) animals, respectively. Five other rats were sacrificed for scar assessment. Eight weeks after cryoinjury heart function in the transplantation, control, and sham groups was measured using a Langendorff preparation. Histologic studies were performed to quantify the extent of the scar and the transplanted cells.
Results. Four weeks after cryoinjury, 36% ± 4% (mean ± 1 standard error) of the left ventricular free wall surface area was scar tissue. At 8 weeks, the scar size had increased (p < 0.01) to 55% ± 3% in the control group. Although the scar size (43% ± 2%) in the transplantation group at 8 weeks was not significantly different from that at 4 weeks, it was less (p < 0.05) than that in the control group. Hearts in the sham group had no scar tissue. The transplanted cardiomyocytes had formed cardiac tissue within the myocardial scar. Systolic and developed pressures in the transplantation group hearts were greater (p = 0.0001) than in the control group hearts but less (p < 0.01) than those in the sham group hearts.
Conclusions. The transplanted cardiomyocytes formed cardiac tissue in the myocardial scar, limited scar expansion, and improved heart function compared with findings in the control hearts.
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Ann. Thorac. Surg. 1996 62: 660-661.
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R. Shahani, J. G. Marshall, B. B. Rubin, R.-K. Li, P. M. Walker, and T. F. Lindsay Role of TNF-alpha in myocardial dysfunction after hemorrhagic shock and lower-torso ischemia Am J Physiol Heart Circ Physiol, March 1, 2000; 278(3): H942 - H950. [Abstract] [Full Text] [PDF]
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R.-K. Li, T. M. Yau, R. D. Weisel, D. A.G. Mickle, T. Sakai, A. Choi, and Z.-Q. Jia CONSTRUCTION OF A BIOENGINEERED CARDIAC GRAFT J. Thorac. Cardiovasc. Surg., February 1, 2000; 119(2): 368 - 375. [Abstract] [Full Text] [PDF]
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R.-K. Li, R. D. Weisel, D. A. G. Mickle, Z.-Q. Jia, E.-J. Kim, T. Sakai, S. Tomita, L. Schwartz, M. Iwanochko, M. Husain, et al. AUTOLOGOUS PORCINE HEART CELL TRANSPLANTATION IMPROVED HEART FUNCTION AFTER A MYOCARDIAL INFARCTION J. Thorac. Cardiovasc. Surg., January 1, 2000; 119(1): 62 - 68. [Abstract] [Full Text] [PDF]
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T. Sakai, R.-K. Li, R. D. Weisel, D. A.G. Mickle, E.-J. Kim, S. Tomita, Z.-Q. Jia, and T. M. Yau Autologous heart cell transplantation improves cardiac function after myocardial injury Ann. Thorac. Surg., December 1, 1999; 68(6): 2074 - 2080. [Abstract] [Full Text] [PDF]
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R.-K. Li, Z.-Q. Jia, R. D. Weisel, D. A. G. Mickle, A. Choi, and T. M. Yau Survival and Function of Bioengineered Cardiac Grafts Circulation, November 9, 1999; 100(90002): II-63 - II-69. [Abstract] [Full Text] [PDF]
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S. Tomita, R.-K. Li, R. D. Weisel, D. A. G. Mickle, E.-J. Kim, T. Sakai, and Z.-Q. Jia Autologous Transplantation of Bone Marrow Cells Improves Damaged Heart Function Circulation, November 9, 1999; 100(90002): II-247 - II-256. [Abstract] [Full Text] [PDF]
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T. Matsushita, M. Oyamada, H. Kurata, S. Masuda, A. Takahashi, T. Emmoto, I. Shiraishi, Y. Wada, T. Oka, and T. Takamatsu Formation of Cell Junctions Between Grafted and Host Cardiomyocytes at the Border Zone of Rat Myocardial Infarction Circulation, November 9, 1999; 100(90002): II-262 - II-268. [Abstract] [Full Text] [PDF]
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T. Sakai, R.-K. Li, R. D. Weisel, D. A.G. Mickle, Z.-Q. Jia, S. Tomita, E.-J. Kim, and T. M. Yau FETAL CELL TRANSPLANTATION: A COMPARISON OF THREE CELL TYPES J. Thorac. Cardiovasc. Surg., October 1, 1999; 118(4): 715 - 725. [Abstract] [Full Text] [PDF]
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H. Reinecke, M. Zhang, T. Bartosek, and C. E. Murry Survival, Integration, and Differentiation of Cardiomyocyte Grafts : A Study in Normal and Injured Rat Hearts Circulation, July 13, 1999; 100(2): 193 - 202. [Abstract] [Full Text] [PDF]
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K. Dipla, J. A. Mattiello, V. Jeevanandam, S. R. Houser, and K. B. Margulies Myocyte Recovery After Mechanical Circulatory Support in Humans With End-Stage Heart Failure Circulation, June 16, 1998; 97(23): 2316 - 2322. [Abstract] [Full Text] [PDF]
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V. J. DiSesa Cardiac Xenotransplantation Ann. Thorac. Surg., December 1, 1997; 64(6): 1858 - 1865. [Abstract] [Full Text]
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J. Leor, H. Prentice, V. Sartorelli, M. J Quinones, M. Patterson, L. K Kedes, and R. A Kloner Gene transfer and cell transplant: an experimental approach to repair a 'broken heart' Cardiovasc Res, September 1, 1997; 35(3): 431 - 441. [Full Text] [PDF]
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R. E. Oakley, N. J. Brand, P. B. Burton, M. C. McMullen, G. B. Adams, M. C. Poznansky, P. J. Barton, and M. H. Yacoub Efficiency of a high-titer retroviral vector for gene transfer into skeletal myoblasts J. Thorac. Cardiovasc. Surg., January 1, 1994; 115(1): 1 - 8. [Abstract] [Full Text] [PDF]
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