ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Sheila G. Haworth
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Komai, H.
Right arrow Articles by Haworth, S. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Komai, H.
Right arrow Articles by Haworth, S. G.

Ann Thorac Surg 1996;62:553-558
© 1996 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Thrombomodulin and Angiotensin-Converting Enzyme Activity During Pediatric Open Heart Operations

Hiroyoshi Komai, MD, Sheila G. Haworth, FRCP

Vascular Biology and Pharmacology Unit, Institute of Child Health, London, England

Accepted for publication April 12, 1996.

Background. Thrombomodulin and angiotensin-converting enzyme are endothelial glycoproteins. The metabolism of these substances is altered when endothelial cells are damaged.

Methods. Serum thrombomodulin level was assayed in 56 children and angiotensin-converting enzyme activity determined in 27 children with congenital heart disease before, during, and after open heart operations.

Results. The thrombomodulin level was significantly higher in children with a high pulmonary blood flow who had pulmonary hypertension than in those with a normal pressure (p < 0.01), and although all patients showed an increase in serum thrombomodulin after coming off cardiopulmonary bypass, the increase was greater in those with preoperative pulmonary hypertension (p < 0.05). Serum angiotensin-converting enzyme activity was normal preoperatively in all children, irrespective of pulmonary arterial pressure, and decreased in all after coming off cardiopulmonary bypass but decreased to a significantly greater extent in those who had pulmonary hypertension preoperatively (p < 0.05).

Conclusions. These findings are compatible with the presence of pulmonary endothelial cell injury and dysfunction before intracardiac repair, which is exacerbated by cardiopulmonary bypass.




This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
B. M. Matata and M. Galinanes
Cardiopulmonary bypass exacerbates oxidative stress but does not increase proinflammatory cytokine release in patients with diabetes compared with patients without diabetesRegulatory effects of exogenous nitric oxide
J. Thorac. Cardiovasc. Surg., July 1, 2000; 120(1): 1 - 11.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
B. M. Matata, A. W. Sosnowski, and M. Galinanes
Off-pump bypass graft operation significantly reduces oxidative stress and inflammation
Ann. Thorac. Surg., March 1, 2000; 69(3): 785 - 791.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
H. Komai, Y. Naito, K. Fujiwara, Y. Noguchi, and Y. Nishimura
Plasma adrenomedullin level after cardiopulmonary bypass
Perfusion, September 1, 1998; 13(5): 334 - 337.
[Abstract] [PDF]

Home page
 PerfusionHome page
H. Komai, Y. Naito, K. Fujiwara, Y. Takagaki, Y. Noguchi, and Y. Nishimura
The protective effect of a leucocyte removal filter on the lung in open-heart surgery for ventricular septal defect
Perfusion, January 1, 1998; 13(1): 27 - 34.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1996 by The Society of Thoracic Surgeons.