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Ann Thorac Surg 1996;62:83-90
© 1996 The Society of Thoracic Surgeons

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Original Articles: Cardiovascular

Inotropes in the Hypoplastic Left Heart Syndrome: Effects in an Animal Model

Division of Thoracic and Cardiovascular Surgery, University of Louisville School of Medicine, Louisville, Kentucky

Background. Despite substantial changes in the surgical treatment of children born with the hypoplastic left heart syndrome, overall mortality remains high. Although further improvements in outcomes appear to depend on more effective perioperative care, few experimental data exist to guide appropriate pharmacologic therapy in these infants. Because different inotropic agents may have different effects on the ratio of pulmonary to systemic flow (Q_p/Q_s), we hypothesize that they may not be equally effective at increasing oxygen delivery.

Methods. In neonatal piglets (n = 6; 3.5 to 6.5 kg), we placed an innominate artery-to-pulmonary artery shunt, created an atrial septal defect, and then occluded right ventricular outflow. We examined the effects of a number of commonly used inotropic agents, administering high and low concentrations of dopamine (5 and 15 µg • kg^-1 • min^-1), dobutamine (5 and 15 µg • kg^-1 • min^-1), and epinephrine (0.05 and 0.1 µg/min).

Results. Dobutamine at 15 µg • kg^-1 • min^-1 increased the Q_p/Q_s ratio from 1.03 ± 0.6 at baseline to 2.52 ± 0.55 (p < 0.05) and decreased oxygen delivery from 50 ± 4.3 to 36 ± 1.7 mL/min (p < 0.1). The arterial-venous oxygen difference increased as oxygen delivery went down, going from 44% ± 1% to 48% ± 2% (p < 0.1). Epinephrine at 0.1 µg • kg^-1 • min^-1 decreased the Q_p/Q_s ratio from 1.23 ± 0.21 to 0.82 ± 0.08 (p < 0.05) and increased oxygen delivery from 40 ± 9.7 to 56 ± 1.7 mL/min (p < 0.05). Systemic venous oxygen saturation increased from 36% ± 4.8% to 50% ± 8.6% (p < 0.05). Although dopamine decreased the Q_p/Q_s ratio and increased oxygen delivery, these changes were not statistically significant.

Conclusions. Dopamine, dobutamine, and epinephrine all increased cardiac output but had substantially different effects on the Q_p/Q_s ratio and on oxygen delivery, possibly due to differential effects on systemic and pulmonary vascular resistances. This suggests that inotropic agents may not be equally beneficial in the clinical setting. Systemic venous oxygen saturation and the arteriovenous oxygen difference may help determine if a given inotrope improves oxygen delivery.

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Discussion
Ann. Thorac. Surg. 1996 62: 90. [Extract] [Full Text]

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