HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): David A. Fullerton Robert C. McIntyre, Jr Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fullerton, D. A. Articles by McIntyre, R. C. Search for Related Content PubMed PubMed Citation Articles by Fullerton, D. A. Articles by McIntyre, R. C., Jr

Ann Thorac Surg 1996;61:1856-1864
© 1996 The Society of Thoracic Surgeons

---

Current Review

Inhaled Nitric Oxide: Therapeutic Applications in Cardiothoracic Surgery

Department of Surgery, University of Colorado, Denver, Colorado

Hypoxemia and increased pulmonary vascular resistance can greatly complicate the management of cardiothoracic surgical patients. These complications are commonly found in the setting of thoracic organ transplantation, adult and pediatric cardiac surgical procedures, and general thoracic surgical procedures. Inhaled nitric oxide is a new therapy that promises to be extremely valuable to the cardiothoracic surgeon. It has been shown to improve oxygenation in the setting of acute lung injury and to selectively lower pulmonary vascular resistance, without producing unwanted systemic vasodilation. The purpose of this review is to discuss the biochemistry, toxicity, experimental studies, and therapeutic applications of inhaled nitric oxide administration in cardiothoracic surgical patients.

This article has been cited by other articles:

				F Urdaneta, E. Lobato, T Beaver, J. Muehlschlegel, D. Kirby, C Klodell, and A Sidi Treating pulmonary hypertension post cardiopulmonary bypass in pigs: milrinone vs. sildenafil analog Perfusion, March 1, 2008; 23(2): 117 - 125. [Abstract] [PDF]

				P. Goyal, U. Kiran, S. Chauhan, R. Juneja, and M. Choudhary Efficacy of nitroglycerin inhalation in reducing pulmonary arterial hypertension in children with congenital heart disease Br. J. Anaesth., August 1, 2006; 97(2): 208 - 214. [Abstract] [Full Text] [PDF]

				E. B. Lobato, T. Beaver, J. Muehlschlegel, D. S. Kirby, C. Klodell, and A. Sidi Treatment with phosphodiesterase inhibitors type III and V: milrinone and sildenafil is an effective combination during thromboxane-induced acute pulmonary hypertension Br. J. Anaesth., March 1, 2006; 96(3): 317 - 322. [Abstract] [Full Text] [PDF]

				R. S Rea, N. T Ansani, and A. L Seybert Role of Inhaled Nitric Oxide in Adult Heart or Lung Transplant Recipients Ann. Pharmacother., May 1, 2005; 39(5): 913 - 917. [Abstract] [Full Text] [PDF]

				A. L. Trachte, E. B. Lobato, F. Urdaneta, P. J. Hess, C. T. Klodell, T. D. Martin, E. D. Staples, and T. M. Beaver Oral Sildenafil Reduces Pulmonary Hypertension After Cardiac Surgery Ann. Thorac. Surg., January 1, 2005; 79(1): 194 - 197. [Abstract] [Full Text] [PDF]

				F. Urdaneta, J. L. Willert, T. Beaver, B. Naik, D. S. Kirby, and E. B. Lobato Effects of a New Phosphodiesterase Enzyme Type V Inhibitor (UK 343-664) Versus Milrinone in a Porcine Model of Acute Pulmonary Hypertension Ann. Thorac. Surg., October 1, 2004; 78(4): 1433 - 1437. [Abstract] [Full Text] [PDF]

				M. R. Bonnell, F. Urdaneta, D. S. Kirby, N. R. Valdez, T. M. Beaver, and E. B. Lobato Effects of sildenafil analogue UK 343-664 on a porcine model of acute pulmonary hypertension Ann. Thorac. Surg., January 1, 2004; 77(1): 238 - 242. [Abstract] [Full Text] [PDF]

				B. Stobierska-Dzierzek, H. Awad, and R. E. Michler The evolving management of acute right-sided heart failure in cardiac transplant recipients J. Am. Coll. Cardiol., October 1, 2001; 38(4): 923 - 931. [Abstract] [Full Text] [PDF]

				D. C. Stuesse, G. D. Giraud, A. A. Vlessis, A. Starr, and D. D. Trunkey Hemodynamic effects of S-nitrosocysteine, an intravenous regional vasodilator J. Thorac. Cardiovasc. Surg., August 1, 2001; 122(2): 371 - 377. [Abstract] [Full Text] [PDF]

				Z. Y. Jiang, T. Costachescu, M. Derouin, and G. Blaise Treatment of pulmonary hypertension during surgery with nitric oxide and vasodilators Can J Anesth, June 1, 2000; 47(6): 552 - 555. [Abstract] [Full Text] [PDF]

				J R Beck, L B Mongero, R M Kroslowitz, A F Choudhri, J M Chen, J J DeRose, M Argenziano, A J Smerling, and M C Oz Inhaled nitric oxide improves hemodynamics in patients with acute pulmonary hypertension after high-risk cardiac surgery Perfusion, January 1, 1999; 14(1): 37 - 42. [Abstract] [PDF]

				D. A. Fullerton, J. Jaggers, M. M. Wollmering, F. Piedalue, F. L. Grover, and R. C. McIntyre Jr Variable Response to Inhaled Nitric Oxide After Cardiac Surgery Ann. Thorac. Surg., May 1, 1997; 63(5): 1251 - 1256. [Abstract] [Full Text]

				M. S. Bhabra, D. N. Hopkinson, T. E. Shaw, and T. L. Hooper Low-Dose Nitric Oxide Inhalation During Initial Reperfusion Enhances Rat Lung Graft Function Ann. Thorac. Surg., February 1, 1997; 63(2): 339 - 344. [Abstract] [Full Text]

				Z. Al-Halees, B. Afrane, M. El-Barbary, D. A. Fullerton, and R. C. McIntyre Jr Magnesium sulfate to facilitate weaning of nitric oxide in pulmonary hypertension. Ann. Thorac. Surg., January 1, 1997; 63(1): 298 - 299. [Full Text]