ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Kai Ihnken
Gerald D. Buckberg
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morita, K.
Right arrow Articles by Ignarro, L. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morita, K.
Right arrow Articles by Ignarro, L. J.

Ann Thorac Surg 1996;61:1775-1780
© 1996 The Society of Thoracic Surgeons

Original Article: Cardiovascular

Pulmonary Vasoconstriction Due to Impaired Nitric Oxide Production After Cardiopulmonary Bypass

Kiyozo Morita, MD, Kai Ihnken, MD, Gerald D. Buckberg, MD, Michael P. Sherman, MD, Louis J. Ignarro, PhD

Division of Cardiothoracic Surgery and bDepartments of Pediatrics and cPharmacology, UCLA School of Medicine, Los Angeles, California

Accepted for publication February 9, 1996.

Background. Pulmonary hypertension is a serious complication after cardiopulmonary bypass (CPB). This study tests the hypothesis that CPB provokes oxidant-mediated pulmonary endothelial dysfunction, leading to reduced nitric oxide (NO) production and pulmonary vasoconstriction.

Methods. Twelve piglets underwent 2 hours of CPB. In 6 of them, CPB prime was supplemented with N-mercaptopropionylglycine and catalase, whereas the others were not treated. Left and right ventricular function were evaluated from end-systolic elastance and Starling analysis. Pulmonary vascular resistance and transpulmonary NO production (measuring NO2-, NO3-) were determined to assess pulmonary endothelial function.

Results. Cardiopulmonary bypass caused a significant increase in pulmonary vascular resistance (83 ± 12 to 212 ± 30 dynes • cm-5 • s kg-1Au: set correctly?, p < 0.05), associated with a reduction of NO production (8.8 ± 1.4 to 2.5 ± 0.5 µmol/min, p < 0.05) and depressed right ventricular function (56 ± 12% of control), whereas N-mercaptopropionylglycine and catalase added to the CPB allowed a substantial improvement of these deleterious effects of CPB.

Conclusions. Cardiopulmonary bypass impairs pulmonary NO production, resulting in pulmonary vasoconstriction and right ventricular dysfunction, which can be reduced by antioxidants. These findings imply the validity of NO inhalation therapy for postoperative pulmonary hypertension as a supplementation of endogenous endothelium-derived relaxing factor.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
S. Nemoto, E. Umehara, T. Ikeda, T. Itonaga, and M. Komeda
Oral Sildenafil Ameliorates Impaired Pulmonary Circulation Early After Bidirectional Cavopulmonary Shunt
Ann. Thorac. Surg., May 1, 2007; 83(5): e11 - e13.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
G. Szabo, P. Soos, S. Bahrle, T. Radovits, E. Weigang, V. Kekesi, B. Merkely, and S. Hagl
Adaptation of the right ventricle to an increased afterload in the chronically volume overloaded heart.
Ann. Thorac. Surg., September 1, 2006; 82(3): 989 - 995.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. El Kebir, B. Hubert, R. Taha, E. Troncy, T. Wang, D. Gauvin, M. Gangal, and G. Blaise
Effects of Inhaled Nitric Oxide on Inflammation and Apoptosis After Cardiopulmonary Bypass
Chest, October 1, 2005; 128(4): 2910 - 2917.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
Y. Lamarche, O. Malo, E. Thorin, A. Denault, M. Carrier, J. Roy, and L.P. Perrault
Inhaled but not intravenous milrinone prevents pulmonary endothelial dysfunction after cardiopulmonary bypass
J. Thorac. Cardiovasc. Surg., July 1, 2005; 130(1): 83 - 92.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. Fortier, R.G. DeMaria, Y. Lamarche, O. Malo, A. Denault, F. Desjardins, M. Carrier, and L.P. Perrault
Inhaled prostacyclin reduces cardiopulmonary bypass-induced pulmonary endothelial dysfunction via increased cyclic adenosine monophosphate levels
J. Thorac. Cardiovasc. Surg., July 1, 2004; 128(1): 109 - 116.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R.-Z. Zhang, Q. Yang, A. P. C. Yim, and G.-W. He
Alteration of cellular electrophysiologic properties in porcine pulmonary microcirculation after preservation with University of Wisconsin and Euro-Collins solutions
Ann. Thorac. Surg., June 1, 2004; 77(6): 1944 - 1950.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
F. D. Wagner, S. Buz, C. Knosalla, R. Hetzer, and B. Hocher
Modulation of Circulating Endothelin-1 and Big Endothelin by Nitric Oxide Inhalation Following Left Ventricular Assist Device Implantation
Circulation, September 9, 2003; 108(90101): II-278 - 284.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
G. Szabo, V. Buhmann, T. Andrasi, N. Stumpf, S. Bahrle, V. Kekesi, S. Hagl, C. Szabo, and A. Juhasz-Nagy
Poly-ADP-ribose polymerase inhibition protects against myocardial and endothelial reperfusion injury after hypothermic cardiac arrest
J. Thorac. Cardiovasc. Surg., September 1, 2003; 126(3): 651 - 658.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
L. G. Fischer, H. V. Aken, and H. Burkle
Management of Pulmonary Hypertension: Physiological and Pharmacological Considerations for Anesthesiologists
Anesth. Analg., June 1, 2003; 96(6): 1603 - 1616.
[Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. Taghavi, H. J. Ankersmit, G. Wieselthaler, M. Gorlitzer, A. Rajek, E. Wolner, and M. Grimm
Extracorporeal membrane oxygenation for graft failure after heart transplantation: Recent Vienna experience
J. Thorac. Cardiovasc. Surg., October 1, 2001; 122(4): 819 - 820.
[Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
H. A. Hennein
Inflammation After Cardiopulmonary Bypass: Therapy for the Postpump Syndrome
Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2001; 5(3): 236 - 255.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
Y. Hayashi, Y. Sawa, N. Fukuyama, H. Nakazawa, and H. Matsuda
Inducible nitric oxide production is an adaptation to cardiopulmonary bypass-induced inflammatory response
Ann. Thorac. Surg., July 1, 2001; 72(1): 149 - 155.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. Nagashima, U. Stock, G. Nollert, J. Sperling, D. Shum-Tim, S. Hatsuoka, and J. E. Mayer Jr
Effects of cyanosis and hypothermic circulatory arrest on lung function in neonatal lambs
Ann. Thorac. Surg., August 1, 1999; 68(2): 499 - 504.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
P. J. Chai, J. A. Williamson, A. J. Lodge, C. W. Daggett, J. E. Scarborough, J. N. Meliones, I. M. Cheifetz, J. J. Jaggers, and R. M. Ungerleider
Effects of ischemia on pulmonary dysfunction after cardiopulmonary bypass
Ann. Thorac. Surg., March 1, 1999; 67(3): 731 - 735.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Serraf, M. Robotin, N. Bonnet, H. Detruit, B. Baudet, M. G. Mazmanian, P. Herve, and C. Planche
ALTERATION OF THE NEONATAL PULMONARY PHYSIOLOGY AFTER TOTAL CARDIOPULMONARY BYPASS
J. Thorac. Cardiovasc. Surg., December 1, 1997; 114(6): 1061 - 1069.
[Abstract] [Full Text]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
N. FINER
Inhaled nitric oxide in neonates
Arch. Dis. Child. Fetal Neonatal Ed., September 1, 1997; 77(2): 81F - 84.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1996 by The Society of Thoracic Surgeons.