| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1996;61:1631-1635
© 1996 The Society of Thoracic Surgeons
Department of Cardiothoracic Surgery, Wythenshawe Hospital, Manchester, United Kingdom
Accepted for publication February 17, 1996.
Background. We have shown previously that lung graft function can be improved by achieving reperfusion with stepwise increments of perfusion pressure over 60 minutes. This study aimed to establish whether similar benefit could be achieved with a shorter, simpler protocol and different storage conditions.
Methods. Rat lungs were flushed with University of Wisconsin or modified Euro-Collins solution and reperfused for 1 hour with blood from a support animal. Grafts were reperfused immediately or after storage at 4°C for 24 hours (University of Wisconsin solution) or 6 hours (Euro-Collins solution). Stored-graft reperfusion was initiated with a 0-, 5-, or 10-minute period during which reperfusion pressure was reduced by 50%.
Results. Stored grafts receiving 0 or 5 minutes of initial low-pressure reperfusion performed poorly, with reduced oxygenation and blood flow and elevated pulmonary artery pressure, airway pressure, and wet/dry weight ratio. In contrast, 10 minutes of initial 50%-pressure reperfusion yielded function comparable with that in controls with both storage conditions.
Conclusions. An initial 10-minute period of 50%-pressure reperfusion improves the function of stored rat lung grafts, whereas 5 minutes is insufficient.
This article has been cited by other articles:
|
|
 |
|
  G. Lang, C. Aigner, G. Winkler, K. Shkirdladze, W. Wisser, G. Dekan, M. Tamura, G. Heinze, D. Van Raemdonck, and W. Klepetko Prolonged venoarterial extracorporeal membrane oxygenation after transplantation restores functional integrity of severely injured lung allografts and prevents the development of pulmonary graft failure in a pig model. J. Thorac. Cardiovasc. Surg., June 1, 2009; 137(6): 1493 - 1498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Bopassa, D. Vandroux, M. Ovize, and R. Ferrera Controlled reperfusion after hypothermic heart preservation inhibits mitochondrial permeability transition-pore opening and enhances functional recovery Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2265 - H2271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Wierup, A. Haraldsson, F. Nilsson, L. Pierre, H. Schersten, M. Silverborn, T. Sjoberg, U. Westfeldt, and S. Steen Ex Vivo Evaluation of Nonacceptable Donor Lungs Ann. Thorac. Surg., February 1, 2006; 81(2): 460 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Schnickel, D. J. Ross, R. Beygui, A. Shefizadeh, H. Laks, R. Saggar, J. P. Lynch III, and A. Ardehali Modified reperfusion in clinical lung transplantation: The results of 100 consecutive cases J. Thorac. Cardiovasc. Surg., January 1, 2006; 131(1): 218 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Bopassa, P. Michel, O. Gateau-Roesch, M. Ovize, and R. Ferrera Low-pressure reperfusion alters mitochondrial permeability transition Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2750 - H2755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Featherstone and D. J. Chambers Long-term hypothermic lung preservation: does adenosine A1 receptor antagonism have a role in ischemic preconditioning protection? Interactive CardioVascular and Thoracic Surgery, March 1, 2004; 3(1): 182 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ardehali, H. Laks, H. Russell, M. Levine, R. Shpiner, S. Lackey, and D. Ross Modified reperfusion and ischemia-reperfusion injury in human lung transplantation J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1929 - 1934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Aguilo, E. Serra, B. Togores, A. de la Pena, C. Santos, and A. G. N. Agusti Long-term (72 hours) preservation of rat lungs J. Thorac. Cardiovasc. Surg., April 1, 2003; 125(4): 907 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. de Perrot and S. Keshavjee Lung preservation Ann. Thorac. Surg., August 1, 2002; 74(2): 629 - 631. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pereszlenyi, G. Lang, H. Steltzer, H. Hetz, A. Kocher, P. Neuhauser, W. Wisser, and W. Klepetko Bilateral lung transplantation with intra- and postoperatively prolonged ECMO support in patients with pulmonary hypertension Eur. J. Cardiothorac. Surg., May 1, 2002; 21(5): 858 - 863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S Allen The role of leukodepletion in limiting ischemia/reperfusion damage in the heart, lung and lower extremity Perfusion, March 1, 2002; 17(2_suppl): 11 - 22. [Abstract] [PDF]
|
|
|
|
|
|
M. Kurusz, J. D Roach Jr, R. A Vertrees, M. K Girouard, and S. D Lick Leukocyte filtration in lung transplantation Perfusion, March 1, 2002; 17(2_suppl): 63 - 67. [Abstract] [PDF]
|
|
|
|
|
|
S. D. Lick, P. S. Brown Jr, M. Kurusz, R. A. Vertrees, C. K. McQuitty, and W. E. Johnston Technique of controlled reperfusion of the transplanted lung in humans Ann. Thorac. Surg., March 1, 2000; 69(3): 910 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. O. Halldorsson, M. T. Kronon, B. S. Allen, S. Rahman, and T. Wang Lowering reperfusion pressure reduces the injury after pulmonary ischemia Ann. Thorac. Surg., January 1, 2000; 69(1): 198 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Featherstone, F. J. Kelly, M. J. Shattock, D. J. Hearse, and D. J. Chambers Hypothermic preservation of isolated rat lungs in modified bicarbonate buffer, EuroCollins solution or St Thomas' Hospital cardioplegic solution Eur. J. Cardiothorac. Surg., November 1, 1999; 14(5): 508 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E.M. Van Raemdonck, N. C.P. Jannis, P. R.J. De Leyn, W. J. Flameng, and T. E. Lerut Alveolar expansion itself but not continuous oxygen supply enhances postmortem preservation of pulmonary grafts Eur. J. Cardiothorac. Surg., April 1, 1999; 13(4): 431 - 441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Pierre, K. N. DeCampos, M. Liu, V. Edwards, E. Cutz, A. S. Slutsky, and S. H. Keshavjee RAPID REPERFUSION CAUSES STRESS FAILURE IN ISCHEMIC RAT LUNGS J. Thorac. Cardiovasc. Surg., December 1, 1998; 116(6): 932 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. O. Halldorsson, M. Kronon, B. S. Allen, S. Rahman, T. Wang, M. Layland, and D. Sidle Controlled reperfusion prevents pulmonary injury after 24 hours of lung preservation Ann. Thorac. Surg., September 1, 1998; 66(3): 877 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Clark, C. Sudarshan, R. Khanna, J. Roughan, P. A. Flecknell, and J. H. Dark Controlled reperfusion and pentoxifylline modulate reperfusion injury after single lung transplantation J. Thorac. Cardiovasc. Surg., June 1, 1998; 115(6): 1335 - 1339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Halldorsson, M. Kronon, B. S. Allen, K. S. Bolling, T. Wang, S. Rahman, H. Feinberg, and R. S. Hartz Controlled Reperfusion After Lung Ischemia: Implications For Improved Function After Lung Transplantation J. Thorac. Cardiovasc. Surg., February 1, 1998; 115(2): 415 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Bhabra, D. N. Hopkinson, T. E. Shaw, N. Onwu, and T. L. Hooper Controlled Reperfusion Protects Lung Grafts During a Transient Early Increase in Permeability Ann. Thorac. Surg., January 1, 1998; 65(1): 187 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Bhabra, D. N. Hopkinson, T. E. Shaw, and T. L. Hooper Low-Dose Nitric Oxide Inhalation During Initial Reperfusion Enhances Rat Lung Graft Function Ann. Thorac. Surg., February 1, 1997; 63(2): 339 - 344. [Abstract] [Full Text]
|
|
|
|
|
|
M. S. Bhabra, D. N. Hopkinson, T. E. Shaw, and T. L. Hooper ATTENUATION OF LUNG GRAFT REPERFUSION INJURY BY A NITRIC OXIDE DONOR J. Thorac. Cardiovasc. Surg., February 1, 1997; 113(2): 327 - 334. [Abstract] [Full Text]
|
|
|
|
|
|
M. S. Bhabra, D. N. Hopkinson, T. E. Shaw, and T. L. Hooper Relative Importance of Prostaglandin/Cyclic Adenosine Monophosphate and Nitric Oxide/Cyclic Guanosine Monophosphate Pathways in Lung Preservation Ann. Thorac. Surg., November 1, 1996; 62(5): 1494 - 1499. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
