ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Steven F. Bolling
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oeltgen, P. R.
Right arrow Articles by Su, T.-P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oeltgen, P. R.
Right arrow Articles by Su, T.-P.

Ann Thorac Surg 1996;61:1488-1493
© 1996 The Society of Thoracic Surgeons

Original Articles: General Thoracic

Extended Lung Preservation With the Use of Hibernation Trigger Factors

Peter R. Oeltgen, PhD, Noel D. Horton, Steven F. Bolling, MD, Tsung-Ping Su, PhD

Department of Pathology and Laboratory Medicine, Pathology Service VA Medical Center, and Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky; Department of Surgery, University of Michigan, Ann Arbor, Michigan; and National Institute on Drug Abuse Addiction Research Center, Baltimore, Maryland

Accepted for publication January 22, 1996.

Background. The complications of preserving lungs for transplantation are well known, with successful transplantation only being assured by preservation times of 5 to 6 hours or less. If a new method of consistent lung preservation could be identified, lung transplantation could be extended to many patients. We have previously reported lung preservation times averaging 14.8 hours using a multiorgan autoperfusion block infused with physiologic saline solution as a model. When plasma from deeply hibernating woodchucks (Marmota monax) or the delta opioid DADLE was infused into the multiorgan block, lung preservation times increased threefold to 45 hours.

Methods. In this study, we examined the effect of infusing plasma containing the hibernation induction trigger molecule on lung preservation for transplantation using a multiorgan autoperfusion block.

Results. This study demonstrated that successful orthotopic transplantation of single canine lungs is possible after 24 to 33 hours of preservation when the lung has been maintained with plasma containing the hibernation induction trigger molecule.

Conclusions. Theoretically, hibernation induction trigger could be administered to donors before lung harvest in an effort to extend lung preservation times.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Sun, M. H. Weil, W. Tang, T. Kamohara, and K. Klouche
{delta}-Opioid receptor agonist reduces severity of postresuscitation myocardial dysfunction
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H969 - H974.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
J. Smith Sonneborn, H. Gottsch, E. Cubin, P. Oeltgen, and P. Thomas
Alternative Strategy for Stress Tolerance: Opioids
J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2004; 59(5): B433 - B440.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
H. V. CAREY, M. T. ANDREWS, and S. L. MARTIN
Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature
Physiol Rev, October 1, 2003; 83(4): 1153 - 1181.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. C. Sigg, J. A. Coles Jr., P. R. Oeltgen, and P. A. Iaizzo
Role of delta -opioid receptor agonists on infarct size reduction in swine
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H1953 - H1960.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. Karck, S. Tanaka, S. F. Bolling, A. Simon, T.-P. Su, P. R. Oeltgen, and A. Haverich
Myocardial protection by ischemic preconditioning and {delta}-opioid receptor activation in the isolated working rat heart
J. Thorac. Cardiovasc. Surg., November 1, 2001; 122(5): 986 - 992.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
D. C. Sigg, J. A. Coles Jr, W. J. Gallagher, P. R. Oeltgen, and P. A. Iaizzo
Opioid preconditioning: myocardial function and energy metabolism
Ann. Thorac. Surg., November 1, 2001; 72(5): 1576 - 1582.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
C. F. Schwartz, A. J. Georges, M. A. Gallagher, L. Yu, K. S. Kilgore, and S. F. Bolling
Delta opioid receptors and low temperature myocardial protection
Ann. Thorac. Surg., December 1, 1999; 68(6): 2089 - 2092.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. E. Benedict, M. B. Benedict, T.-P. Su, and S. F. Bolling
Opiate Drugs and {delta}-Receptor-Mediated Myocardial Protection
Circulation, November 9, 1999; 100(90002): II-357 - 360.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
L.-I Tsao, B. Ladenheim, A. M. Andrews, C. C. Chiueh, J. L. Cadet, and T.-P. Su
Delta Opioid Peptide [D-Ala2,D-leu5]Enkephalin Blocks the Long-term Loss of Dopamine Transporters Induced by Multiple Administrations of Methamphetamine: Involvement of Opioid Receptors and Reactive Oxygen Species
J. Pharmacol. Exp. Ther., October 1, 1998; 287(1): 322 - 331.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
S. F. Bolling, N. L. Tramontini, K. S. Kilgore, T.-P. Su, P. R. Oeltgen, and H. H. Harlow
Use of "Natural" Hibernation Induction Triggers for Myocardial Protection
Ann. Thorac. Surg., September 1, 1997; 64(3): 623 - 627.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1996 by The Society of Thoracic Surgeons.