| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1996;61:1453-1457
© 1996 The Society of Thoracic Surgeons
Department of Surgery, University of Virginia, Charlottesville, Virginia
Background. Adult respiratory distress syndrome remains a major cause of morbidity and mortality. We investigated the role of thromboxane receptor antagonism in an experimental model of acute lung injury that mimics adult respiratory distress syndrome.
Methods. Three groups of rabbit heart-lung preparations were studied for 30 minutes in an ex vivo blood perfusion/ventilation system. Saline control (SC) lungs received saline solution during the first 20 minutes of study. Injury control (IC) lungs received an oleic acid-ethanol solution during the first 20 minutes. Thromboxane receptor blockade (TRB) lungs received the same injury as IC lungs, but a thromboxane receptor antagonist (SQ30741) was added to the blood perfusate just prior to study. Blood gases were obtained at 10-minute intervals, and tidal volume, pulmonary artery pressure, and lung weight were continuously recorded. Oxygenation was assessed by measuring the percent change in oxygen tension over the 30-minute study period. Tissue samples were collected from all lungs for histologic evaluation.
Results. Significant differences were found between SC and IC lungs as well as TRB and IC lungs when comparing pulmonary artery pressure (SC = 33.1 ± 2.2 mm Hg, TRB = 35.4 ± 2.1 mm Hg, IC = 60.4 ± 11.1 mm Hg; p < 0.02) and percent change in oxygenation (SC = -20.6% ± 10.3%, TRB = -24.2% ± 9.5%, IC = -57.1% ± 6.2%; p < 0.03). None of the other variables demonstrated significant differences.
Conclusions. Thromboxane receptor blockade prevents the pulmonary hypertension and the decline in oxygenation seen in an experimental model of acute lung injury that mimics adult respiratory distress syndrome.
Related Article
Ann. Thorac. Surg. 1996 61: 1457.
This article has been cited by other articles:
|
|
 |
|
  R. Gerrah, A. Elami, A. Stamler, A. Smirnov, and Z. Stoeger Preoperative Aspirin Administration Improves Oxygenation in Patients Undergoing Coronary Artery Bypass Grafting Chest, May 1, 2005; 127(5): 1622 - 1626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Reed General thoracic surgery and the Southern Thoracic Surgical Association: the second 25 years Ann. Thorac. Surg., November 1, 2003; 76(90050): S14 - 16. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Raiden, K. Nahmod, V. Nahmod, G. Semeniuk, Y. Pereira, C. Alvarez, M. Giordano, and J. R. Geffner Nonpeptide Antagonists of AT1 Receptor for Angiotensin II Delay the Onset of Acute Respiratory Distress Syndrome J. Pharmacol. Exp. Ther., October 1, 2002; 303(1): 45 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Janssen Isoprostanes: an overview and putative roles in pulmonary pathophysiology Am J Physiol Lung Cell Mol Physiol, June 1, 2001; 280(6): L1067 - L1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Young, C. S. Rayhrer, T. D. Edmisten, G. A. Cephas, C. G. Tribble, and I. L. Kron Sodium nitroprusside mitigates oleic acid-induced acute lung injury Ann. Thorac. Surg., January 1, 2000; 69(1): 224 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Rayhrer, T. D. Edmisten, G. A. Cephas, C. G. Tribble, I. L. Kron, and J. S. Young Nitric Oxide Potentiates Acute Lung Injury in an Isolated Rabbit Lung Model Ann. Thorac. Surg., April 1, 1998; 65(4): 935 - 938. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
