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Ann Thorac Surg 1996;61:963-968
© 1996 The Society of Thoracic Surgeons

Original Articles: General Thoracic

ET-Kyoto Solution for 48-Hour Canine Lung Preservation

Hiromi Wada, MD, Tatsuo Fukuse, MD, Takayuki Nakamura, MD, Chun Jiang Liu, MD, Toru Bando, MD, Shinji Kosaka, MD, Tetsuya Ariyasu, MD, Shigeki Hitomi, MD

Department of Thoracic Surgery, Chest Disease Research Institute, Kyoto University, Kyoto, Japan

Accepted for publication November 1, 1995.

Background. ET-Kyoto (ET-K) solution, proven safe for 20-hour lung preservation, was modified to achieve longer preservation: ET-K2 solution with more buffer capacity and ET-K3 solution with less potassium.

Methods. Lungs were preserved with one of the three solutions (with prostaglandin E1) at 4°C for 48 hours (n = 5 for each). Left lung transplantation was performed and evaluated for 6 hours.

Results. Each solution became acidic after preservation (p < 0.01), though the change was lowest in the ET-K2 solution. All animals in the ET-K and ET-K3 groups survived for 6 hours after reperfusion, but only 1 survived in the ET-K2 group (p < 0.05). In all groups, partial pressure of oxygen in arterial blood decreased gradually after reperfusion. Pulmonary vascular resistance after reperfusion was significantly lower in the ET-K group than in the ET-K3 group (p < 0.01). Scanning electron microscopic examination showed that endothelial cell swelling and disruption were milder in the ET-K group (with solution containing potassium of 44 mEq/L) than in the ET-K3 group.

Conclusion. Lung preservation can be achieved for 48 hours in ET-K and ET-K3 solutions. Enhancement of buffer capacity provides no advantage. Potassium at 44 mEq/L does not cause deterioration of endothelial cells.




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