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Ann Thorac Surg 1996;61:760-768
© 1996 The Society of Thoracic Surgeons

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Current Review

Optimal Myocardial Preservation: Cooling, Cardioplegia, and Conditioning

Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado

Myocardial preservation techniques have evolved in conjunction with cardiac surgery and currently offer substantial protection against myocardial injury. We propose that cardiac preconditioning, a robust, endogenous mechanism of cardioprotection, is emerging as an important adjunct to current cardioplegic techniques. By reviewing the physiologic basis for current cardioplegic strategies, and understanding the cardioprotective benefits of preconditioning, we postulate that cardiac preconditioning may represent an important, clinically accessible component of myocardial protection.

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