HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yokoi, K. Articles by Arai, T. Search for Related Content PubMed PubMed Citation Articles by Yokoi, K. Articles by Arai, T. Related Collections Related Article

Ann Thorac Surg 1996;61:546-550
© 1996 The Society of Thoracic Surgeons

---

Original Article: General Thoracic

Brain Metastasis in Resected Lung Cancer: Value of Intensive Follow-up With Computed Tomography

Divisions of Thoracic Surgery and Neurosurgery, Tochigi Cancer Center, Utsunomiya, Japan

Accepted for publication October 28, 1995.

Background. Brain metastases are a common mode of recurrence in resected lung cancer and are usually associated with an ominous outcome.

Methods. To assess the usefulness of follow-up using computed tomography of the brain for early detection and effective treatment of brain metastases, we prospectively studied 128 patients with completely resected non–small cell lung cancer. Follow-up computed tomographic scans were obtained every 2 to 6 months over 24 postoperative months in 69 patients and every 2 months for 6 postoperative months in 59.

Results. Brain metastases were discovered in 11 patients (8.6%), and 7 patients were neurologically asymptomatic when the metastases were diagnosed. Single metastasis was found in 5 patients and multiple metastases in 6. The maximal size of all but one lesion was less than 25 mm. The median survival time and 5-year survival rate in all 11 patients with brain metastases were 10 months and 24%, respectively. Furthermore, those in 7 asymptomatic patients were 25 months and 38%, respectively.

Conclusions. We consider intensive follow-up with computed tomography to be worthwhile for early detection and effective treatment of brain metastases in patients with completely resected lung cancer.

Related Article

Invited Commentary

Kumarasingham Jeyasingham
Ann. Thorac. Surg. 1996 61: 551. [Extract] [Full Text]

This article has been cited by other articles:

				K. E. Posther, L. M. McCall, D. H. Harpole Jr., C. E. Reed, J. B. Putnam Jr., V. W. Rusch, and B. A. Siegel Yield of Brain 18F-FDG PET in Evaluating Patients with Potentially Operable Non-Small Cell Lung Cancer J. Nucl. Med., October 1, 2006; 47(10): 1607 - 1611. [Abstract] [Full Text] [PDF]

				E. M. Marom, H. P. McAdams, J. J. Erasmus, P. C. Goodman, D. K. Culhane, R. E. Coleman, J. E. Herndon, and E. F. Patz Jr Staging Non-Small Cell Lung Cancer with Whole-Body PET Radiology, September 1, 1999; 212(3): 803 - 809. [Abstract] [Full Text]

				F. E. IV, J. H. Ryu, G. M. Miller, P. H. Luetmer, L. A. Forstrom, O. L. Burnett, C. M. Rowland, S. J. Swensen, and D. E. Midthun Suspected Non–Small Cell Lung Cancer: Incidence of Occult Brain and Skeletal Metastases and Effectiveness of Imaging for Detection—Pilot Study Radiology, April 1, 1999; 211(1): 137 - 145. [Abstract] [Full Text]

				C. A.B. Saunders, J. E. Dussek, M. J. O'Doherty, and M. N. Maisey Evaluation of fluorine-18-fluorodeoxyglucose whole body positron emission tomography imaging in the staging of lung cancer Ann. Thorac. Surg., March 1, 1999; 67(3): 790 - 797. [Abstract] [Full Text] [PDF]

				K. Yokoi, N. Kamiya, H. Matsuguma, S. Machida, T. Hirose, K. Mori, and K. Tominaga Detection of Brain Metastasis in Potentially Operable Non-small Cell Lung Cancer: A Comparison of CT and MRI Chest, March 1, 1999; 115(3): 714 - 719. [Abstract] [Full Text] [PDF]