HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Ian M. Mitchell James C. S. Pollock Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mitchell, I. M. Articles by Jamieson, M. P. G. Search for Related Content PubMed PubMed Citation Articles by Mitchell, I. M. Articles by Jamieson, M. P. G.

Ann Thorac Surg 1995;60:1741-1744
© 1995 The Society of Thoracic Surgeons

---

Original Articles: Cardiovascular

Effects of Dopamine on Liver Blood Flow in Children With Congenital Heart Disease

Department of Cardiac Surgery, Royal Hospital for Sick Children, Glasgow, Scotland

Accepted for publication August 3, 1995.

Background. A reduction in liver function is common after cardiac operations, particularly in children with preexisting cardiac failure. The etiology is multifactorial, but the redistribution of organ blood flow that occurs during cardiopulmonary bypass implicates ischemia as one of the principal causes of injury. Dopamine hydrochloride is known to have specific effects on the renal circulation, and the aim of this study was to investigate its effects on hepatic perfusion.

Methods. Eight children with congenital heart disease were studied 6 hours after the end of cardiopulmonary bypass when they were fully rewarmed and hemodynamically stable. Using noninvasive auricular densitometry, we determined the percent disappearance rate of indocyanine green as an index of liver blood flow both before and 1 hour after commencing an infusion of dopamine at 4 µg•kg^-1•min^-1.

Results. Results showed an increase of approximately 31% in the percent disappearance rate of indocyanine green with the addition of low-dose dopamine (4 µg •kg^-1•min^-1) (p < 0.01).

Conclusions. Dopamine may have a therapeutic role in increasing hepatic perfusion and minimizing any loss in liver function.

This article has been cited by other articles:

				J. Li, G. Zhang, H. Holtby, T. Humpl, C. A. Caldarone, G. S. Van Arsdell, and A. N. Redington Adverse Effects of Dopamine on Systemic Hemodynamic Status and Oxygen Transport in Neonates After the Norwood Procedure J. Am. Coll. Cardiol., November 7, 2006; 48(9): 1859 - 1864. [Abstract] [Full Text] [PDF]