| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1995;60:1573-1581
© 1995 The Society of Thoracic Surgeons
Northern California PET Imaging Center and Radiological Associates of Sacramento, Sacramento, California
Background. A need exists for an accurate, noninvasive means of staging non-small cell lung cancer.
Methods. A prospective evaluation of regional and whole-body positron emission tomography (PET) imaging for staging lung cancer was carried out in 99 patients. Mediastinal PET and computed tomography findings were compared with results of surgical staging in 76 patients. Those PET and computed tomography findings that indicated possible distant metastasis were compared with biopsy results and the results of clinical and imaging follow-up.
Results. Sensitivity and specificity for the diagnosis of N2 disease were 83% and 94% for PET and 63% and 73% for computed tomography, respectively. Positron emission tomography showed previously unsuspected distant metastasis in 11 patients (11%), with no demonstrated false-positive results. Normal PET findings were obtained at distant sites of computed tomography abnormality in 19 patients (19%). Clinical and imaging follow-up in 14 of these patients showed no evidence of metastasis. In 1 case, the PET result proved to be falsely negative.
Conclusions. Imaging with PET was more accurate than computed tomography for diagnosis of mediastinal and distant metastasis. Detection of unsuspected metastatic disease by PET may permit reduction in the number of thoracotomies performed for nonresectable disease.
Related Articles
Ann. Thorac. Surg. 1995 60: 1581-1582.
Ann. Thorac. Surg. 1995 60: 1582.
This article has been cited by other articles:
|
|
 |
|
  Y. C. Ung, D. E. Maziak, J. A. Vanderveen, C. A. Smith, K. Gulenchyn, C. Lacchetti, W. K. Evans, and Lung Cancer Disease Site Group of Cancer Care Onta 18Fluorodeoxyglucose Positron Emission Tomography in the Diagnosis and Staging of Lung Cancer: A Systematic Review J Natl Cancer Inst, December 5, 2007; 99(23): 1753 - 1767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ebihara, H. Nomori, K. Watanabe, T. Ohtsuka, T. Naruke, K. Uno, I. Kuwahira, and K. Eguchi Characteristics of Advantages of Positron Emission Tomography over Computed Tomography for N-staging in Lung Cancer Patients Jpn. J. Clin. Oncol., November 1, 2006; 36(11): 694 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Posther, L. M. McCall, D. H. Harpole Jr., C. E. Reed, J. B. Putnam Jr., V. W. Rusch, and B. A. Siegel Yield of Brain 18F-FDG PET in Evaluating Patients with Potentially Operable Non-Small Cell Lung Cancer J. Nucl. Med., October 1, 2006; 47(10): 1607 - 1611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. F. Munden, S. S. Swisher, C. W. Stevens, and D. J. Stewart Imaging of the Patient with Non-Small Cell Lung Cancer Radiology, December 1, 2005; 237(3): 803 - 818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Birim, A. P. Kappetein, and A. J.J.C. Bogers Reply Ann. Thorac. Surg., November 1, 2005; 80(5): 1980 - 1981. [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Halpern, C. Schiepers, W. A. Weber, T. L. Crawford, B. J. Fueger, M. E. Phelps, and J. Czernin Presurgical Staging of Non-small Cell Lung Cancer: Positron Emission Tomography, Integrated Positron Emission Tomography/CT, and Software Image Fusion Chest, October 1, 2005; 128(4): 2289 - 2297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sachs and T. V. Bilfinger The Impact of Positron Emission Tomography on Clinical Decision Making in a University-Based Multidisciplinary Lung Cancer Practice Chest, August 1, 2005; 128(2): 698 - 703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Birim, A. P. Kappetein, T. Stijnen, and A. J.J.C. Bogers Meta-Analysis of Positron Emission Tomographic and Computed Tomographic Imaging in Detecting Mediastinal Lymph Node Metastases in Nonsmall Cell Lung Cancer Ann. Thorac. Surg., January 1, 2005; 79(1): 375 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Schrevens, N. Lorent, C. Dooms, and J. Vansteenkiste The Role of PET Scan in Diagnosis, Staging, and Management of Non-Small Cell Lung Cancer Oncologist, November 1, 2004; 9(6): 633 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Aquino and A. J. Fischman Does Whole-Body 2-[18F]-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Have an Advantage Over Thoracic Positron Emission Tomography for Staging Patients With Lung Cancer? Chest, September 1, 2004; 126(3): 755 - 760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Lynch, C. D. Wright, N. C. Choi, S. L. Aquino, and E. J. Mark Case 26-2004 - A 56-Year-Old Woman with Cough and a Lung Nodule N. Engl. J. Med., August 19, 2004; 351(8): 809 - 817. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tomita, Y. Matsuzaki, M. Edagawa, T. Shimizu, M. Hara, and T. Onitsuka Combined Procedures for Mediastinal Staging in Non-small Cell Lung Cancer Asian Cardiovasc Thorac Ann, June 1, 2004; 12(2): 125 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. C. Detterbeck, S. Falen, M. P. Rivera, J. S. Halle, and M. A. Socinski Seeking a Home for a PET, Part 1: Defining the Appropriate Place for Positron Emission Tomography Imaging in the Diagnosis of Pulmonary Nodules or Masses Chest, June 1, 2004; 125(6): 2294 - 2299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J. Schaffler, G. Wolf, H. Schoellnast, R. Groell, A. Maier, F. M. Smolle-Juttner, M. Woltsche, G. Fasching, R. Nicoletti, and R. M. Aigner Non-Small Cell Lung Cancer: Evaluation of Pleural Abnormalities on CT Scans with 18F FDG PET Radiology, June 1, 2004; 231(3): 858 - 865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Nomori, K. Watanabe, T. Ohtsuka, T. Naruke, K. Suemasu, and K. Uno The size of metastatic foci and lymph nodes yielding false-negative and false-positive lymph node staging with positron emission tomography in patients with lung cancer J. Thorac. Cardiovasc. Surg., April 1, 2004; 127(4): 1087 - 1092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sharma, P. Fidias, L. A. Hayman, S. L. Loomis, K. H. Taber, and S. L. Aquino Patterns of Lymphadenopathy in Thoracic Malignancies RadioGraphics, March 1, 2004; 24(2): 419 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Pfister, D. H. Johnson, C. G. Azzoli, W. Sause, T. J. Smith, S. Baker Jr, J. Olak, D. Stover, J. R. Strawn, A. T. Turrisi, et al. American Society of Clinical Oncology Treatment of Unresectable Non-Small-Cell Lung Cancer Guideline: Update 2003 J. Clin. Oncol., January 15, 2004; 22(2): 330 - 353. [Full Text] [PDF]
|
|
|
|
|
|
J. D. Bradley, C. A. Perez, F. Dehdashti, and B. A. Siegel Implementing Biologic Target Volumes in Radiation Treatment Planning for Non-Small Cell Lung Cancer J. Nucl. Med., January 1, 2004; 45(90010): 96S - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Gould, W. G. Kuschner, C. E. Rydzak, C. C. Maclean, A. N. Demas, H. Shigemitsu, J. K. Chan, and D. K. Owens Test Performance of Positron Emission Tomography and Computed Tomography for Mediastinal Staging in Patients with Non-Small-Cell Lung Cancer: A Meta-Analysis Ann Intern Med, December 2, 2003; 139(11): 879 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Reed, D. H. Harpole, K. E. Posther, S. L. Woolson, R. J. Downey, B. F. Meyers, R. T. Heelan, H. A. MacApinlac, S.-H. Jung, G. A. Silvestri, et al. Results of the American College of Surgeons Oncology Group Z0050 trial: the utility of positron emission tomography in staging potentially operable non-small cell lung cancer J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1943 - 1951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. P. Massion and D. P. Carbone From Clinical and Pathologic to Molecular Staging of Lung Cancer Am. J. Respir. Crit. Care Med., June 15, 2003; 167(12): 1587 - 1588. [Full Text] [PDF]
|
|
|
|
|
|
J. K. LeBlanc, R. Espada, and G. Ergun Non-small Cell Lung Cancer Staging Techniques and Endoscopic Ultrasound: Tissue Is Still the Issue Chest, May 1, 2003; 123(5): 1718 - 1725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Kostakoglu, H. Agress Jr, and S. J. Goldsmith Clinical Role of FDG PET in Evaluation of Cancer Patients RadioGraphics, March 1, 2003; 23(2): 315 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Gupta, J. S. Rogers, G. M. Graeber, J. L. Gregory, U. Waheed, D. Mullet, and M. Atkins Clinical Role of F-18 Fluorodeoxyglucose Positron Emission Tomography Imaging in Patients With Lung Cancer and Suspected Malignant Pleural Effusion Chest, December 1, 2002; 122(6): 1918 - 1924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Vesselle, J. M. Pugsley, E. Vallieres, and D. E. Wood The impact of fluorodeoxyglucose F 18 positron-emission tomography on the surgical staging of non-small cell lung cancer J. Thorac. Cardiovasc. Surg., September 1, 2002; 124(3): 511 - 519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Hollings and P. Shaw Diagnostic imaging of lung cancer Eur. Respir. J., April 1, 2002; 19(4): 722 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Aquino, J. C. Asmuth, R. H. Moore, S. B. Weise, and A. J. Fischman Improved Image Interpretation with Registered Thoracic CT and Positron Emission Tomography Data Sets Am. J. Roentgenol., April 1, 2002; 178(4): 939 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. H. Kernstine, K. A. McLaughlin, Y. Menda, N. P. Rossi, D. J. Kahn, D. L. Bushnell, M. M. Graham, C. K. Brown, and M. T. Madsen Can FDG-PET reduce the need for mediastinoscopy in potentially resectable nonsmall cell lung cancer? Ann. Thorac. Surg., February 1, 2002; 73(2): 394 - 402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A G Pitman, R J Hicks, D S Binns, R E Ware, V Kalff, A F McKenzie, D L Ball, and M P MacManus Performance of sodium iodide based 18F-fluorodeoxyglucose positron emission tomography in the characterization of indeterminate pulmonary nodules or masses Br. J. Radiol., February 1, 2002; 75(890): 114 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.F. Vansteenkiste Imaging in lung cancer: positron emission tomography scan Eur. Respir. J., February 1, 2002; 19(35_suppl): 49S - 60s. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A M Kerstjens, H. J Groen, and W. van der Bij Recent advances: Respiratory medicine BMJ, December 8, 2001; 323(7325): 1349 - 1353. [Full Text] [PDF]
|
|
|
|
|
|
R. J. Hicks, V. Kalff, M. P. MacManus, R. E. Ware, A. Hogg, A. F. McKenzie, J. P. Matthews, and D. L. Ball 18F-FDG PET Provides High-Impact and Powerful Prognostic Stratification in Staging Newly Diagnosed Non-Small Cell Lung Cancer J. Nucl. Med., November 1, 2001; 42(11): 1596 - 1604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S F Barrington Whole body applications of positron emission tomography in oncology Imaging, September 1, 2001; 13(3): 185 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Laking and P Price 18-Fluorodeoxyglucose positron emission tomography (FDG-PET) and the staging of early lung cancer Thorax, September 1, 2001; 56(90002): ii38 - 44. [Full Text] [PDF]
|
|
|
|
|
|
N. C. Gupta, W. J. Tamim, G. G. Graeber, H. A. Bishop, and G. R. Hobbs Mediastinal Lymph Node Sampling Following Positron Emission Tomography With Fluorodeoxyglucose Imaging in Lung Cancer Staging Chest, August 1, 2001; 120(2): 521 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Gambhir, J. Czernin, J. Schwimmer, D. H. S. Silverman, R. E. Coleman, and M. E. Phelps A Tabulated Summary of the FDG PET Literature J. Nucl. Med., May 1, 2001; 42(90050): 1S - 93. [Full Text] [PDF]
|
|
|
|
|
|
J.F. Vansteenkiste and S.G. Stroobants The role of positron emission tomography with 18F-fluoro-2-deoxy-D-glucose in respiratory oncology Eur. Respir. J., April 1, 2001; 17(4): 802 - 820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-P. Hauber, K. H. Bohuslavizki, C. H. Lund, A. Fritscher-Ravens, A. Meyer, and A. Pforte Positron Emission Tomography in the Staging of Small-Cell Lung Cancer : A Preliminary Study Chest, March 1, 2001; 119(3): 950 - 954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Dunagan, R. Chin Jr., T. W. McCain, L. D. Case, B. A. Harkness, T. Oaks, and E. F. Haponik Staging by Positron Emission Tomography Predicts Survival in Patients With Non-small Cell Lung Cancer Chest, February 1, 2001; 119(2): 333 - 339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Kalff, R. J. Hicks, M. P. MacManus, D. S. Binns, A. F. McKenzie, R. E. Ware, A. Hogg, and D. L. Ball Clinical Impact of 18F Fluorodeoxyglucose Positron Emission Tomography in Patients With Non-Small-Cell Lung Cancer: A Prospective Study J. Clin. Oncol., January 1, 2001; 19(1): 111 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. McCain, D. P. Dunagan, R. Chin Jr., T. Oaks, B. A. Harkness, and E. F. Haponik The Usefulness of Positron Emission Tomography in Evaluating Patients for Pulmonary Malignancies Chest, December 1, 2000; 118(6): 1610 - 1615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. F. Roberts, D. M. Follette, D. von Haag, J. A. Park, P. E. Valk, T. R. Pounds, and D. M. Hopkins Factors associated with false-positive staging of lung cancer by positron emission tomography Ann. Thorac. Surg., October 1, 2000; 70(4): 1154 - 1159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Andre, D. Grunenwald, J.-P. Pignon, A. Dujon, J. L. Pujol, P. Y. Brichon, L. Brouchet, E. Quoix, V. Westeel, and T. Le Chevalier Survival of Patients With Resected N2 Non-Small-Cell Lung Cancer: Evidence for a Subclassification and Implications J. Clin. Oncol., August 16, 2000; 18(16): 2981 - 2989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Pieterman, J. W.G. van Putten, J. J. Meuzelaar, E. L. Mooyaart, W. Vaalburg, G. H. Koeter, V. Fidler, J. Pruim, and H. J.M. Groen Preoperative Staging of Non-Small-Cell Lung Cancer with Positron-Emission Tomography N. Engl. J. Med., July 27, 2000; 343(4): 254 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Erasmus, H. P. McAdams, S. E. Rossi, P. C. Goodman, R. E. Coleman, and E. F. Patz FDG PET of Pleural Effusions in Patients with Non--Small Cell Lung Cancer Am. J. Roentgenol., July 1, 2000; 175(1): 245 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Farrell, H. P. McAdams, J. E. Herndon, and E. F. Patz Jr Non-Small Cell Lung Cancer: FDG PET for Nodal Staging in Patients with Stage I Disease Radiology, June 1, 2000; 215(3): 886 - 890. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Carretta, C. Landoni, G. Melloni, G. L. Ceresoli, A. Compierchio, F. Fazio, and P. Zannini 18-FDG positron emission tomography in the evaluation of malignant pleural diseases - a pilot study Eur. J. Cardiothorac. Surg., April 1, 2000; 17(4): 377 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Deslauriers and J. Gregoire Clinical and Surgical Staging of Non-Small Cell Lung Cancer Chest, April 1, 2000; 117(4_suppl_1): 96S - 103S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Gupta, G. M. Graeber, and H. A. Bishop Comparative Efficacy of Positron Emission Tomography With Fluorodeoxyglucose in Evaluation of Small (<1 cm), Intermediate (1 to 3 cm), and Large (>3 cm) Lymph Node Lesions Chest, March 1, 2000; 117(3): 773 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Dwamena, S. S. Sonnad, J. O. Angobaldo, and R. L. Wahl Metastases from Non-Small Cell Lung Cancer: Mediastinal Staging in the 1990s-Meta-analytic Comparison Of PET and CT Radiology, November 1, 1999; 213(2): 530 - 536. [Abstract] [Full Text]
|
|
|
|
|
|
J. R. Roberts, M. G. Blum, R. Arildsen, D. C. Drinkwater Jr, K. R. Christian, T. A. Powers, and W. H. Merrill Prospective comparison of radiologic, thoracoscopic, and pathologic staging in patients with early non-small cell lung cancer Ann. Thorac. Surg., October 1, 1999; 68(4): 1154 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. H. Kernstine, W. Stanford, B. F. Mullan, N. P. Rossi, B. H. Thompson, D. L. Bushnell, K. A. McLaughlin, and J. A. Kern PET, CT, and MRI with Combidex for mediastinal staging in non-small cell lung carcinoma Ann. Thorac. Surg., September 1, 1999; 68(3): 1022 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Marom, H. P. McAdams, J. J. Erasmus, P. C. Goodman, D. K. Culhane, R. E. Coleman, J. E. Herndon, and E. F. Patz Jr Staging Non-Small Cell Lung Cancer with Whole-Body PET Radiology, September 1, 1999; 212(3): 803 - 809. [Abstract] [Full Text]
|
|
|
|
|
|
G. M. Graeber, N. C. Gupta, and G. F. Murray POSITRON EMISSION TOMOGRAPHIC IMAGING WITH FLUORODEOXYGLUCOSE IS EFFICACIOUS IN EVALUATING MALIGNANT PULMONARY DISEASE J. Thorac. Cardiovasc. Surg., April 1, 1999; 117(4): 719 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. Scott, J. Shepherd, and S. S. Gambhir Cost-effectiveness of FDG-PET for staging non-small cell lung cancer: a decision analysis Ann. Thorac. Surg., December 1, 1998; 66(6): 1876 - 1883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Weder, R. A. Schmid, H. Bruchhaus, S. Hillinger, G. K. von Schulthess, and H. C. Steinert Detection of extrathoracic metastases by positron emission tomography in lung cancer Ann. Thorac. Surg., September 1, 1998; 66(3): 886 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. J Lowe and K. S Naunheim Current role of positron emission tomography in thoracic oncology Thorax, August 1, 1998; 53(8): 703 - 712. [Full Text]
|
|
|
|
|
|
V. J. Lowe and K. S. Naunheim Positron Emission Tomography in Lung Cancer Ann. Thorac. Surg., June 1, 1998; 65(6): 1821 - 1829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Luketich, P. R. Schauer, C. C. Meltzer, R. J. Landreneau, G. K. Urso, D. W. Townsend, P. F. Ferson, R. J. Keenan, and C. P. Belani Role of Positron Emission Tomography in Staging Esophageal Cancer Ann. Thorac. Surg., September 1,&nbs |
