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Ann Thorac Surg 1995;60:1406-1408
© 1995 The Society of Thoracic Surgeons

Case Reports

Heart Transplantation for Chagas' Cardiomyopathy

Carlos Blanche, MD, Ivan Aleksic, MD, Johanna J. M. Takkenberg, MD, Lawrence S. C. Czer, MD, Michael C. Fishbein, MD, Alfredo Trento, MD

Department of Cardiothoracic Surgery, Cedars-Sinai Medical Center, Los Angeles, California

Accepted for publication April 28, 1995.

We present 2 patients who underwent orthotopic heart transplantation for end-stage Chagas' cardiomyopathy. Despite immunosuppressive therapy, postoperative prophylaxis with nifurtimox appeared to prevent Trypanosoma cruzi reactivation. Neither patient has shown signs of Chagas' myocarditis, and both are clinically well 12 and 72 months after transplantation. The successful outcome of our patients suggests that heart transplantation is a reasonable therapeutic option in patients with end-stage Chagas' cardiomyopathy.


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Invited Commentary
Noedir A. G. Stolf
Ann. Thorac. Surg. 1995 60: 1408-1409. [Extract] [Full Text]



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