ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Falk-Udo Sack
Bernhard Voss
Raffaele De Simone
Siegfried Hagl
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lange, R.
Right arrow Articles by Hagl, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lange, R.
Right arrow Articles by Hagl, S.

Ann Thorac Surg 1995;60:1219-1225
© 1995 The Society of Thoracic Surgeons

Articles

Treatment of dilated cardiomyopathy with dynamic cardiomyoplasty: The heidelberg experience

MD Rüdiger Lange*, MD Falk-Udo Sack, MD Bernhard Voss, MD Raffaele De Simone, Matthias Thielman, MD Angélique Nair, MD Johannes Brachmann, MD Rainer Haussmann, MD Franz Fleischer, MD Siegfried Hagl

Abt Herzchirurgie, Abt Innere Medizin III, and Klinik für Anaesthesiologie, Universitätsklinik, Heidelberg, Germany

Accepted for publication May 31, 1995.

* Address reprint requests to Dr Lange, Abt Herzchirurgie, Chirurgische Universitätsklinik, INF 110, 69120 Heidelberg, Germany.

Background.: Data concerning the efficacy of dynamic cardiomyoplasty are still inconsistent, especially in terms of improvement of left ventricular function.

Methods.: Between August 1990 and February 1994, eight isolated cardiomyoplasty procedures were performed in patients with cardiomyopathy (ejection fraction, 0.14 to 0.32; New York Heart Association class III) and contraindications to heart transplantation.

Results.: Follow-up was 41.1 ± 14.1 months. One patient died 2 months and another 3 years after operation. Considerable symptomatic improvement was found in 6 of 7 patients, 3 of whom went back to work. One patient with severe pulmonary hypertension exhibited no improvement. Mean New York Heart Association-class decreased from 3.0 to 1.9 (p < 0.001). Echocardiography showed an increase in fractional shortening and in peak aortic flow velocity in all patients. Left ventricular ejection fraction increased from 0.21 ± 0.05 to 0.38 ± 0.16 (n = 7, p < 0.015) at 1 year, to 0.37 ± 0.18 (n = 6, p < 0.05) at 2 years, and to 0.36 ± 0.19 (n = 5, not significant) at 3 years. Pulmonary artery pressure tended to decrease over time. No significant change in exercise level or maximal oxygen consumption during treadmill testing was observed.

Conclusions.: Our preliminary results show that patients may exhibit an impressive clinical improvement after cardiomyoplasty, with only moderate changes in objective hemodynamic indices. We do not consider cardiomyoplasty an alternative to heart transplantation, but reserve it for patients with contraindications to heart transplantation.




This article has been cited by other articles:


Home page
 Eur J Cardiothorac SurgHome page
J. C. Chachques, O. J. Jegaden, V. Bors, T. Mesana, C. Latremouille, P. A. Grandjean, J. N. Fabiani, and A. Carpentier
Heart transplantation following cardiomyoplasty: a biological bridge
Eur J Cardiothorac Surg, April 1, 2008; 33(4): 685 - 690.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
M P HAYWARD
Dynamic cardiomyoplasty: time to wrap it up?
Heart, September 1, 1999; 82(3): 263 - 264.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1995 by The Society of Thoracic Surgeons.