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Si M. Pham
Robert J. Keenan
Robert L. Kormos
Akihiko Kawai
Brack G. Hattler
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Bartley P. Griffith
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Ann Thorac Surg 1995;60:1015-1020
© 1995 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Perioperative Donor Bone Marrow Infusion Augments Chimerism in Heart and Lung Transplant Recipients

Si M. Pham, MD, Robert J. Keenan, MD, Abdul S. Rao, MD, DPhil, Paulo A. Fontes, MD, Robert L. Kormos, MD, Kareem Abu-Elmagd, MD, Adriana Zeevi, PhD, Akihiko Kawai, MD, Brack G. Hattler, MD, PhD, Robert L. Hardesty, MD, Anthony J. Demetris, MD, Massimo M. Trucco, MD, Gayle L. Rosner, PhD, John J. Fung, MDPhD, Thomas E. Starzl, MD, PhD, Bartley P. Griffith, MD

Pittsburgh Transplantation Institute and the Departments of Surgery and Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania

Background. We and others have demonstrated that a low level of donor cell chimerism was present for years after transplantation in tissues and peripheral blood of heart and lung recipients; it was associated, in the latter, with a lower incidence of chronic rejection. To augment this phenomenon, we initiated a trial combining simultaneous infusion of donor bone marrow with heart or lung allotransplantation.

Methods. Between September 1993 and January 1995, 15 nonconditioned patients received either heart (n = 10) or lung (n = 5) allografts concurrently with an infusion of unmodified donor bone marrow (3.0 x 108 cells/kg), and were maintained on an immunosuppressive regimen consisting of tacrolimus and steroids.

Results. There was no complication associated with the infusion of donor bone marrow. Chimerism was detectable in 73% of bone marrow--augmented patients up to the last sample tested. Of the 5 control recipients who did not receive bone marrow infusion, only 1 had detectable chimerism by flow on postoperative day 15, which dwindled to an undetectable level by postoperative day 36. None of the patients had evidence of donor-specific immune modulation by mixed lymphocyte reaction.

Conclusions. The combined infusion of donor bone marrow and heart or lung transplantation, without preconditioning of the recipient, is safe and is associated with an augmentation of donor cell chimerism.


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Discussion
Ann. Thorac. Surg. 1995 60: 1020. [Extract] [Full Text]



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