| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1995;60:760-766
© 1995 The Society of Thoracic Surgeons
Division of Cardiology, Medical College of Virginia, Richmond, Virginia
Abstract
Repeated brief ischemic episodes result in prolonged depression of contractile function despite the absence of irreversible damage, a phenomenon called myocardial stunning. Considerable evidence exists to suggest that oxygen radicals, particularly the hydroxyl radical formed as a result of Fenton reaction or nitric oxide-peroxynitrite pathway, may contribute to the pathogenesis of myocardial stunning. The generation of free radicals may cause sarcoplasmic reticulum dysfunction, and both of these mechanisms may lead to calcium overload, which in turn could exacerbate the damage initiated by oxygen radicals. Antioxidant therapy has been shown to effectively attenuate or even prevent the development of prolonged depression of contractility in many studies. In addition, preconditioning with brief ischemic insults is able to trigger protection, which appears to attenuate stunning 24 to 48 hours later. The mechanism of this protection is not known, although one or more members of the heat shock protein family may have a role in protection against stunning.
This article has been cited by other articles:
|
|
 |
|
  X. Li, K. Tang, B. Xie, S. Li, and G. J. Rozanski Regulation of Kv4 channel expression in failing rat heart by the thioredoxin system Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H416 - H424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Y. Peng, N. J. Serkova, D. J. Kominsky, J. L. Brown, and P. E. Wischmeyer Glutamine-Mediated Attenuation of Cellular Metabolic Dysfunction and Cell Death After Injury Is Dependent on Heat Shock Factor-1 Expression JPEN J Parenter Enteral Nutr, September 1, 2006; 30(5): 373 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tanaka, F. Gunawan, R. D. Terry, K. Inagaki, A. D. Caffarelli, G. Hoyt, P. S. Tsao, D. Mochly-Rosen, and R. C. Robbins Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators J. Thorac. Cardiovasc. Surg., May 1, 2005; 129(5): 1160 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tanaka, G. K. Mokhtari, R. D. Terry, L. B. Balsam, K.-H. Lee, T. Kofidis, P. S. Tsao, and R. C. Robbins Overexpression of Human Copper/Zinc Superoxide Dismutase (SOD1) Suppresses Ischemia-Reperfusion Injury and Subsequent Development of Graft Coronary Artery Disease in Murine Cardiac Grafts Circulation, September 14, 2004; 110(11_suppl_1): II-200 - II-206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Y. Xu, S. P. Kuppusamy, J. Q. Wang, H. Li, H. Cui, T. M. Dawson, P. L. Huang, A. L. Burnett, P. Kuppusamy, and L. C. Becker Nitric Oxide Protects Cardiac Sarcolemmal Membrane Enzyme Function and Ion Active Transport against Ischemia-induced Inactivation J. Biol. Chem., October 24, 2003; 278(43): 41798 - 41803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Singh and H. K. Saini Resident Cardiac Mast Cells and Ischemia-Reperfusion Injury Journal of Cardiovascular Pharmacology and Therapeutics, June 1, 2003; 8(2): 135 - 148. [Abstract] [PDF]
|
|
|
|
|
|
J. Jayakumar, K. Suzuki, I. A. Sammut, R. T. Smolenski, M. Khan, N. Latif, H. Abunasra, B. Murtuza, M. Amrani, and M. H. Yacoub Heat Shock Protein 70 Gene Transfection Protects Mitochondrial and Ventricular Function Against Ischemia-Reperfusion Injury Circulation, September 18, 2001; 104 (2009): I-303 - I-307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Schad, W. Heimisch, G. P. Eising, and N. Mendler Effect of dopamine and atrial pacing on stunned myocardium Eur. J. Cardiothorac. Surg., June 1, 1999; 13(6): 710 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Jayakumar, R. T. Smolenski, C. C. Gray, A. T. Goodwin, K. Kalsi, M. Amrani, and M. H. Yacoub Influence of heat stress on myocardial metabolism and functional recovery after cardioplegic arrest: a 31P N.M.R study Eur. J. Cardiothorac. Surg., April 1, 1999; 13(4): 467 - 474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kuhn-Regnier, E. Natour, S. Dhein, O. Dapunt, H. J. Geissler, K. LaRose, C. Gorg, and U. Mehlhorn Beta-blockade versus Buckberg blood-cardioplegia in coronary bypass operation Eur. J. Cardiothorac. Surg., January 1, 1999; 15(1): 67 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Wippermann, F. X. Schmid, B. Eberle, R. G. Huth, C. Kampmann, D. Schranz, and H. Oelert Reduced inotropic support after aprotinin therapy during pediatric cardiac operations Ann. Thorac. Surg., January 1, 1999; 67(1): 173 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Wang, H. Chen, H. Qin, S. Sankarapandi, M. W. Becher, P. C. Wong, and J. L. Zweier Overexpression of human copper,zinc-superoxide dismutase (SOD1) prevents postischemic injury PNAS, April 14, 1998; 95(8): 4556 - 4560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wang and JayL. Zweier Measurement of Nitric Oxide and Peroxynitrite Generation in the Postischemic Heart. EVIDENCE FOR PEROXYNITRITE-MEDIATED REPERFUSION INJURY J. Biol. Chem., November 15, 1996; 271(46): 29223 - 29230. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
