ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Jonathan C. Nesbitt
Joe B. Putnam, Jr
Garrett L. Walsh
Jack A. Roth
Clifton F. Mountain
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nesbitt, J. C.
Right arrow Articles by Mountain, C. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nesbitt, J. C.
Right arrow Articles by Mountain, C. F.

Ann Thorac Surg 1995;60:466-472
© 1995 The Society of Thoracic Surgeons

Current Reviews

Survival in Early-Stage Non—Small Cell Lung Cancer

Jonathan C. Nesbitt, MD, Joe B. Putnam, Jr, MD, Garrett L. Walsh, MD, Jack A. Roth, MD, Clifton F. Mountain, MD

Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

The duration of survival in early-stage lung cancer (stages I and II) varies between reports in the literature. Several reasons account for this: patient population heterogeneity, inconsistent staging, anatomic variability, dissimilar tumor morphology, and unpredictable tumor biology. This report addresses some of the issues in early-stage non-small cell lung cancer that relate to variability between estimates of survival in end stage reporting. We review several large series since the introduction of the International Staging System in 1986 and other selected, contemporary reports that address end results in patients with pathologic stage I or stage II lung cancer. Overall survival for patients with pathologic stage I disease is 64.6% (range, 55% to 72%) and 41.2% for patients with stage II disease (range, 29% to 51%). Reducing morphologic differences by placing patients in groups based on the TNM subset and refinement in categorization by matching TNM subsets based on histology and other factors can improve considerably homogeneity and enhance prognostic predictability. The development of more accurate measures for predicting prognosis may serve to clarify the roles of primary and adjuvant treatment, particularly in those patients with early-stage disease associated with poor prognostic factors in whom the potential for long-term survival is reduced.




This article has been cited by other articles:


Home page
 JCOHome page
P. M. Kenny, M. T. King, R. C. Viney, M. J. Boyer, C. A. Pollicino, J. M. McLean, M. J. Fulham, and B. C. McCaughan
Quality of Life and Survival in the 2 Years After Surgery for Non-Small-Cell Lung Cancer
J. Clin. Oncol., January 10, 2008; 26(2): 233 - 241.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
O. Rena, L. Carsana, S. Cristina, E. Papalia, F. Massera, L. Errico, C. Bozzola, and C. Casadio
Lymph node isolated tumor cells and micrometastases in pathological stage I non-small cell lung cancer: prognostic significance
Eur. J. Cardiothorac. Surg., December 1, 2007; 32(6): 863 - 867.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
J.-J. Hung, C.-Y. Wang, M.-H. Huang, B.-S. Huang, W.-H. Hsu, and Y.-C. Wu
Prognostic factors in resected stage I non small cell lung cancer with a diameter of 3 cm or less: Visceral pleural invasion did not influence overall and disease-free survival
J. Thorac. Cardiovasc. Surg., September 1, 2007; 134(3): 638 - 643.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
P. C. Lee, J. L. Port, R. J. Korst, Y. Liss, D. N. Meherally, and N. K. Altorki
Risk Factors for Occult Mediastinal Metastases in Clinical Stage I Non-Small Cell Lung Cancer
Ann. Thorac. Surg., July 1, 2007; 84(1): 177 - 181.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
B. D. Vincent, M. Fraig, and G. A. Silvestri
A Pilot Study of Narrow-Band Imaging Compared to White Light Bronchoscopy for Evaluation of Normal Airways and Premalignant and Malignant Airways Disease
Chest, June 1, 2007; 131(6): 1794 - 1799.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Kobayashi, H. Kubo, T. Suzuki, K. Ishizawa, M. Yamada, M. He, Y. Yamamoto, H. Yamamoto, H. Sasano, H. Sasaki, et al.
Endogenous Secretory Receptor for Advanced Glycation End Products in Non-Small Cell Lung Carcinoma
Am. J. Respir. Crit. Care Med., January 15, 2007; 175(2): 184 - 189.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Vierikko, R. Jarvenpaa, T. Autti, P. Oksa, M. Huuskonen, S. Kaleva, J. Laurikka, S. Kajander, K. Paakkola, S. Saarelainen, et al.
Chest CT screening of asbestos-exposed workers: lung lesions and incidental findings
Eur. Respir. J., January 1, 2007; 29(1): 78 - 84.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
P. C. Lee, R. J. Korst, J. L. Port, Y. Kerem, A. L. Kansler, and N. K. Altorki
Long-term survival and recurrence in patients with resected non-small cell lung cancer 1 cm or less in size
J. Thorac. Cardiovasc. Surg., December 1, 2006; 132(6): 1382 - 1388.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. Potti, S. Mukherjee, R. Petersen, H. K. Dressman, A. Bild, J. Koontz, R. Kratzke, M. A. Watson, M. Kelley, G. S. Ginsburg, et al.
A Genomic Strategy to Refine Prognosis in Early-Stage Non-Small-Cell Lung Cancer
N. Engl. J. Med., August 10, 2006; 355(6): 570 - 580.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
T. Okamoto, R. Maruyama, R. Suemitsu, Y. Aoki, H. Wataya, M. Kojo, and Y. Ichinose
Prognostic value of the histological subtype in completely resected non-small cell lung cancer
Interactive CardioVascular and Thoracic Surgery, August 1, 2006; 5(4): 362 - 366.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
Bronchogenic Carcinoma Cooperative Group of the Sp
Survival of 2,991 Patients With Surgical Lung Cancer: The Denominator Effect in Survival
Chest, October 1, 2005; 128(4): 2274 - 2281.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. V. Scagliotti and on behalf of the Adjuvant Lung Cancer Project Ital
The ALPI Trial: The Italian/European Experience with Adjuvant Chemotherapy in Resectable Non-Small Lung Cancer
Clin. Cancer Res., July 1, 2005; 11(13): 5011s - 5016s.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. P. Wisnivesky, T. McGinn, C. Henschke, P. Hebert, M. C. Iannuzzi, and E. A. Halm
Ethnic Disparities in the Treatment of Stage I Non-Small Cell Lung Cancer
Am. J. Respir. Crit. Care Med., May 15, 2005; 171(10): 1158 - 1163.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
O. Tiffet, A. G. Nicholson, A. Khaddage, N. Prevot, G. Ladas, F. Dubois, and P. Goldstraw
Feasibility of the Detection of the Sentinel Lymph Node in Peripheral Non-small Cell Lung Cancer With Radio Isotopic and Blue Dye Techniques
Chest, February 1, 2005; 127(2): 443 - 448.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. C. Viney, M. J. Boyer, M. T. King, P. M. Kenny, C. A. Pollicino, J. M. McLean, B. C. McCaughan, and M. J. Fulham
Randomized Controlled Trial of the Role of Positron Emission Tomography in the Management of Stage I and II Non-Small-Cell Lung Cancer
J. Clin. Oncol., June 15, 2004; 22(12): 2357 - 2362.
[Abstract] [Full Text] [PDF]

Home page
 Asian Cardiovasc. Thorac. Ann.Home page
A. Campione, T. Ligabue, L. Luzzi, C. Ghiribelli, P. Paladini, L. Voltolini, M. Di Bisceglie, M. Lonzi, and G. Gotti
Impact of Size, Histology, and Gender on Stage IA Non-Small Cell Lung Cancer
Asian Cardiovasc Thorac Ann, June 1, 2004; 12(2): 149 - 153.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
B. Jeremic, F. B. Zimmermann, C. Nieder, and M. M. Molls
Radiation therapy alone as an alternative to surgery in patients with early stage non-small-cell lung cancer having cardiovascular (and other) comorbidity
Eur. J. Cardiothorac. Surg., February 1, 2004; 25(2): 297 - 297.
[Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
Y.-C. Wu, C.-F. J. Lin, W.-H. Hsu, B.-S. Huang, M.-H. Huang, and L.-S. Wang
Long-term results of pathological stage I non-small cell lung cancer: validation of using the number of totally removed lymph nodes as a staging control
Eur. J. Cardiothorac. Surg., December 1, 2003; 24(6): 994 - 1001.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
V. Ambrogi, E. Pompeo, S. Elia, G. R. Pistolese, and T. C. Mineo
The impact of cardiovascular comorbidity on the outcome of surgery for stage I and II non-small-cell lung cancer
Eur. J. Cardiothorac. Surg., May 1, 2003; 23(5): 811 - 817.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. S. Kinch, M.-B. Moore, and D. H. Harpole Jr.
Predictive Value of the EphA2 Receptor Tyrosine Kinase in Lung Cancer Recurrence and Survival
Clin. Cancer Res., February 1, 2003; 9(2): 613 - 618.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
T. Osaki, T. Oyama, C.-D. Gu, T. Yamashita, T. So, M. Takenoyama, K. Sugio, and K. Yasumoto
Prognostic Impact of Micrometastatic Tumor Cells in the Lymph Nodes and Bone Marrow of Patients With Completely Resected Stage I Non-Small-Cell Lung Cancer
J. Clin. Oncol., July 1, 2002; 20(13): 2930 - 2936.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Tomizawa, T. Kohno, H. Kondo, A. Otsuka, M. Nishioka, T. Niki, T. Yamada, A. Maeshima, K. Yoshimura, R. Saito, et al.
Clinicopathological Significance of Epigenetic Inactivation of RASSF1A at 3p21.3 in Stage I Lung Adenocarcinoma
Clin. Cancer Res., July 1, 2002; 8(7): 2362 - 2368.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. Collins, E. A. Kazerooni, J. Lacomis, H. P. McAdams, A. N. Leung, M. Shiau, J. Semenkovich, and R. B. Love
Bronchogenic Carcinoma after Lung Transplantation: Frequency, Clinical Characteristics, and Imaging Findings
Radiology, July 1, 2002; 224(1): 131 - 138.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
D. L. Miller, C. M. Rowland, C. Deschamps, M. S. Allen, V. F. Trastek, and P. C. Pairolero
Surgical treatment of non-small cell lung cancer 1 cm or less in diameter
Ann. Thorac. Surg., May 1, 2002; 73(5): 1545 - 1551.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. Lopez-Encuentra, J. L. Duque-Medina, R. Rami-Porta, A. G. de la Camara, and P. Ferrando
Staging in Lung Cancer: Is 3 cm a Prognostic Threshold in Pathologic Stage I Non-small Cell Lung Cancer? : A Multicenter Study of 1,020 Patients
Chest, May 1, 2002; 121(5): 1515 - 1520.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. A. D'Amico, T. A. Aloia, M.-B. H. Moore, D. H. Conlon, J. E. Herndon II, M. S. Kinch, and D. H. Harpole Jr
Predicting the sites of metastases from lung cancer using molecular biologic markers
Ann. Thorac. Surg., October 1, 2001; 72(4): 1144 - 1148.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
A.J. Poncelet, B. Weynand, F. Ferdin, A.R. Robert, and P.H. Noirhomme
Bone marrow micrometastasis might not be a short-term predictor of survival in early stages non-small cell lung carcinoma
Eur. J. Cardiothorac. Surg., September 1, 2001; 20(3): 481 - 488.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
N. Altorki, M. Kent, and M. Pasmantier
Detection of early-stage lung cancer: Computed tomographic scan or chest radiograph?
J. Thorac. Cardiovasc. Surg., June 1, 2001; 121(6): 1053 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
N. A. Obuchowski, R. J. Graham, M. E. Baker, and K. A. Powell
Ten Criteria for Effective Screening: Their Application to Multislice CT Screening for Pulmonary and Colorectal Cancers
Am. J. Roentgenol., June 1, 2001; 176(6): 1357 - 1362.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. P. Siegenthaler, K. M. Pisters, K. W. Merriman, J. A. Roth, S. G. Swisher, G. L. Walsh, A. A. Vaporciyan, W. R. Smythe, and J. B. Putnam Jr
Preoperative chemotherapy for lung cancer does not increase surgical morbidity
Ann. Thorac. Surg., April 1, 2001; 71(4): 1105 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Tokunou, T. Niki, K. Eguchi, S. Iba, H. Tsuda, T. Yamada, Y. Matsuno, H. Kondo, Y. Saitoh, H. Imamura, et al.
c-MET Expression in Myofibroblasts : Role in Autocrine Activation and Prognostic Significance in Lung Adenocarcinoma
Am. J. Pathol., April 1, 2001; 158(4): 1451 - 1463.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
H. Han, J. F. Silverman, T. S. Santucci, R. S. Macherey, T. A. dAmato, M. Y. Tung, R. J. Weyant, and R. J. Landreneau
Vascular Endothelial Growth Factor Expression in Stage I Non-Small Cell Lung Cancer Correlates With Neoangiogenesis and a Poor Prognosis
Ann. Surg. Oncol., January 1, 2001; 8(1): 72 - 79.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
G. Massard, X. Ducrocq, M. Beaufigeau, S. Elia, R. Kessler, J.-F. Herve, and J.-M. Wihlm
Lung cancer following previous extrapulmonary malignancy
Eur. J. Cardiothorac. Surg., November 1, 2000; 18(5): 524 - 528.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
P. M. Boiselle, A. Ernst, and D. D. Karp
Lung Cancer Detection in the 21st Century: Potential Contributions and Challenges of Emerging Technologies
Am. J. Roentgenol., November 1, 2000; 175(5): 1215 - 1221.
[Full Text] [PDF]

Home page
 ChestHome page
A. T. Schroen, F. C. Detterbeck, R. Crawford, M. P. Rivera, and M. A. Socinski
Beliefs Among Pulmonologists and Thoracic Surgeons in the Therapeutic Approach to Non-small Cell Lung Cancer
Chest, July 1, 2000; 118(1): 129 - 137.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. N. ROM, J. G. HAY, T. C. LEE, Y. JIANG, and K.-M. TCHOU-WONG
Molecular and Genetic Aspects of Lung Cancer
Am. J. Respir. Crit. Care Med., April 1, 2000; 161(4): 1355 - 1367.
[Full Text]

Home page
 ChestHome page
J. Deslauriers and J. Gregoire
Surgical Therapy of Early Non-Small Cell Lung Cancer
Chest, April 1, 2000; 117(4_suppl_1): 104S - 109S.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. Nemunaitis, S. G. Swisher, T. Timmons, D. Connors, M. Mack, L. Doerksen, D. Weill, J. Wait, D. D. Lawrence, B. L. Kemp, et al.
Adenovirus-Mediated p53 Gene Transfer in Sequence With Cisplatin to Tumors of Patients With Non-Small-Cell Lung Cancer
J. Clin. Oncol., February 1, 2000; 18(3): 609 - 609.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. H. Park, Y. M. Shim, H. J. Baek, M.-S. Kim, D. H. Choe, K.-J. Cho, C.-T. Lee, and J. I. Zo
Postoperative adjuvant therapy for stage II non-small-cell lung cancer
Ann. Thorac. Surg., November 1, 1999; 68(5): 1821 - 1826.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Marchetti, G. Bertacca, F. Buttitta, A. Chella, G. Quattrocolo, C. A. Angeletti, and G. Bevilacqua
Telomerase Activity as a Prognostic Indicator in Stage I Non-Small Cell Lung Cancer
Clin. Cancer Res., August 1, 1999; 5(8): 2077 - 2081.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
T. Fujisawa, T. Iizasa, Y. Saitoh, Y. Sekine, S.-i. Motohashi, T. Yasukawa, K. Shibuya, K. Hiroshima, and H. Ohwada
Smoking Before Surgery Predicts Poor Long-Term Survival in Patients With Stage I Non-Small-Cell Lung Carcinomas
J. Clin. Oncol., July 1, 1999; 17(7): 2086 - 2086.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. Riquet, D. Manac'h, F. Le Pimpec-Barthes, A. Dujon, and A. Chehab
Prognostic significance of surgical-pathologic N1 disease in non-small cell carcinoma of the lung
Ann. Thorac. Surg., June 1, 1999; 67(6): 1572 - 1576.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. A. Adebonojo, A. N. Bowser, D. M. Moritz, and P. C. Corcoran
Impact of Revised Stage Classification of Lung Cancer on Survival: A Military Experience
Chest, June 1, 1999; 115(6): 1507 - 1513.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. A. D'Amico, MD, M. Massey, MD, J. E. Herndon II, PhD, M.-B. Moore, and D. H. Harpole Jr
A BIOLOGIC RISK MODEL FOR STAGE I LUNG CANCER: IMMUNOHISTOCHEMICAL ANALYSIS OF 408 PATIENTS WITH THE USE OF TEN MOLECULAR MARKERS
J. Thorac. Cardiovasc. Surg., April 1, 1999; 117(4): 736 - 743.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
I. G. Duarte, B. L. Bufkin, M. F. Pennington, A. A. Gal, C. Cohen, A. S. Kosinski, K. A. Mansour, and J. I. Miller
Angiogenesis As A Predictor Of Survival After Surgical Resection For Stage I Non-Small-Cell Lung Cancer
J. Thorac. Cardiovasc. Surg., March 1, 1998; 115(3): 652 - 659.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. Padilla, V. Calvo, J. C. Penalver, G. Sales, and A. Morcillo
Surgical Results and Prognostic Factors in Early Non-Small Cell Lung Cancer
Ann. Thorac. Surg., February 1, 1997; 63(2): 324 - 326.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
W.-W. Lai, M.-H. Wu, J.-J. Yan, and F.-F. Chen
Immunohistochemical Analysis of nm23-H1 in Stage I Non-Small Cell Lung Cancer: A Useful Marker in Prediction of Metastases
Ann. Thorac. Surg., November 1, 1996; 62(5): 1500 - 1504.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1995 by The Society of Thoracic Surgeons.