HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Temeck, B. K. Articles by Pass, H. I. Search for Related Content PubMed PubMed Citation Articles by Temeck, B. K. Articles by Pass, H. I.

Ann Thorac Surg 1995;59:1385-1390
© 1995 The Society of Thoracic Surgeons

Metastasectomy for Sarcomatous Pediatric Histologies: Results and Prognostic Factors

Thoracic Oncology Section, Pediatric Oncology Section, and Biostatistics and Data Management Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

We reviewed our experience of pediatric metastasectomy to define (1) morbidity/mortality in this population and (2) any preoperative or intraoperative prognostic predictors of survival. One hundred fifty-two patients with median age 19 years (range, 5 to 33 years) had 258 thoracic explorations (Ewing's sarcoma, 28; rhabdomyosarcoma, 6; nonrhabdomyosarcoma soft tissue sarcoma, 42; and osteosarcoma, 76). Resections were accomplished by 218 wedge resections, 19 anatomic resections, 14 wedge and anatomic resections, 4 wedge and chest wall resections, and 3 wedge resections/other procedures. An initial complete resection was accomplished in 121/152 patients (80%). With a median potential follow-up of 10.6 years, median survival from initial thoracotomy is 2.2 years. By the Cox proportional hazards model, three or more positive nodules (p = 0.021), histology other than osteosarcoma (p = 0.0054), and incomplete resection (p < 0.0001) were unfavorable prognostic factors for survival. Two or more positive nodules (p = 0.0049), left location (p = 0.0031), age 14 years or greater at diagnosis (p = 0.0052), or rhabdomyosarcoma (p = 0.0066) predicted shorter pulmonary progression–free survivals after resection. Nonrhabdomyosarcoma pediatric metastasectomy can yield selected long-term survival. Morbidity/mortality is low, and a complete resection, if possible, is paramount. Prognostic factors can be defined that can be used to define the limits of this therapy to the patient and family.

This article has been cited by other articles:

				B. Kempf-Bielack, S. S. Bielack, H. Jurgens, D. Branscheid, W. E. Berdel, G. U. Exner, U. Gobel, K. Helmke, G. Jundt, H. Kabisch, et al. Osteosarcoma Relapse After Combined Modality Therapy: An Analysis of Unselected Patients in the Cooperative Osteosarcoma Study Group (COSS) J. Clin. Oncol., January 20, 2005; 23(3): 559 - 568. [Abstract] [Full Text] [PDF]

				A. P. Staddon, R. Lackman, K. Robinson, J. B. Shrager, and M. Warhol Osteogenic Sarcoma Presenting with Lung Metastasis Oncologist, April 1, 2002; 7(2): 144 - 153. [Abstract] [Full Text] [PDF]

				B. K. Temeck, L. H. Wexler, S. M. Steinberg, L. L. McClure, M. A. Horowitz, and H. I. Pass Reoperative pulmonary metastasectomy for sarcomatous pediatric histologies Ann. Thorac. Surg., September 1, 1998; 66(3): 908 - 913. [Abstract] [Full Text] [PDF]