HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Etievent, J.-P. Articles by Kantelip, J.-P. Search for Related Content PubMed PubMed Citation Articles by Etievent, J.-P. Articles by Kantelip, J.-P.

Ann Thorac Surg 1995;59:1192-1194
© 1995 The Society of Thoracic Surgeons

Use of Cardiac Troponin I as a Marker of Perioperative Myocardial Ischemia

Department of Thoracic and Cardiovascular Surgery and Department of Pharmacology, Saint-Jacques Hospital, Besancon, France

Accepted for publication February 3, 1995.

Troponin I is a contractile protein comprising three isoforms, two related to the skeletal muscle and one to the cardiac fibers. Cardiac troponin I (CTn I) is specific, without any cross-reactivity with the other two. Several studies have demonstrated its release after acute myocardial infarction. In contrast, CTn I never has been found in a healthy population, marathon runners, people with skeletal disease, or patients undergoing non-cardiac operations. Thus, CTn I is a more specific marker of cardiac damage than common serum enzymes. It is also more sensitive, allowing diagnosis of perioperative microinfarction and detection of acute myocardial infarction much earlier after the onset of ischemia (4 hours). Using a rapid one-step assay, we measured the release of CTn I in two groups of patients after operation: 20 with calcified aortic stenosis and normal coronary arteries (aortic valve replacement group and control group) and 20 undergoing coronary artery bypass grafting. In the overall population CTn I peaked at hour 6 and practically disappeared after day 5. Mean values were higher in the coronary artery bypass grafting group. In the aortic valve replacement group, a positive correlation was found between aortic cross-clamping time and CTn I, which is a reliable marker of cardiac ischemia during heart operations and can be used to evaluate cardioprotective procedures.

This article has been cited by other articles:

				L. Petaja, M. Salmenpera, K. Pulkki, and V. Pettila Biochemical Injury Markers and Mortality After Coronary Artery Bypass Grafting: A Systematic Review. Ann. Thorac. Surg., June 1, 2009; 87(6): 1981 - 1992.e3. [Abstract] [Full Text] [PDF]

				J. D. Stearns, V. G. Davila-Roman, B. Barzilai, R. E. Thompson, K. L. Grogan, B. Thomas, and C. W. Hogue Jr Prognostic Value of Troponin I Levels for Predicting Adverse Cardiovascular Outcomes in Postmenopausal Women Undergoing Cardiac Surgery Anesth. Analg., March 1, 2009; 108(3): 719 - 726. [Abstract] [Full Text] [PDF]

				L. Tritapepe, V. De Santis, D. Vitale, F. Guarracino, F. Pellegrini, P. Pietropaoli, and M. Singer Levosimendan pre-treatment improves outcomes in patients undergoing coronary artery bypass graft surgery Br. J. Anaesth., February 1, 2009; 102(2): 198 - 204. [Abstract] [Full Text] [PDF]

				V. A. Mannacio, D. Iorio, V. De Amicis, F. Di Lello, and F. Musumeci Effect of rosuvastatin pretreatment on myocardial damage after coronary surgery: a randomized trial. J. Thorac. Cardiovasc. Surg., December 1, 2008; 136(6): 1541 - 1548. [Abstract] [Full Text] [PDF]

				F. F. Immer, A. Ackermann, E. Gygax, M. Stalder, L. Englberger, F. S. Eckstein, H. T. Tevaearai, J. Schmidli, and T. P. Carrel Minimal Extracorporeal Circulation is a Promising Technique for Coronary Artery Bypass Grafting Ann. Thorac. Surg., November 1, 2007; 84(5): 1515 - 1521. [Abstract] [Full Text] [PDF]

				A. Kulik, F. D. Rubens, D. Gunning, M. E. Bourke, T. G. Mesana, and M. Ruel Radial Artery Graft Treatment With Phenoxybenzamine is Clinically Safe and May Reduce Perioperative Myocardial Injury Ann. Thorac. Surg., February 1, 2007; 83(2): 502 - 509. [Abstract] [Full Text] [PDF]

				K. Rouine-Rapp, K. P. Rouillard, W. Miller-Hance, N. H. Silverman, K. K. Collins, M. K. Cahalan, A. Bostrom, and I. A. Russell Segmental Wall-Motion Abnormalities After an Arterial Switch Operation Indicate Ischemia Anesth. Analg., November 1, 2006; 103(5): 1139 - 1146. [Abstract] [Full Text] [PDF]

				J. A. Symons and P. S. Myles Myocardial protection with volatile anaesthetic agents during coronary artery bypass surgery: a meta-analysis Br. J. Anaesth., August 1, 2006; 97(2): 127 - 136. [Abstract] [Full Text] [PDF]

				I. Koramaz, Z. Pulathan, S. Usta, S. C. Karahan, A. Alver, E. Yaris, N. I. Kalyoncu, and F. Ozcan Cardioprotective Effect of Cold-Blood Cardioplegia Enriched with N-Acetylcysteine During Coronary Artery Bypass Grafting Ann. Thorac. Surg., February 1, 2006; 81(2): 613 - 618. [Abstract] [Full Text] [PDF]

				B. Ji, M. Liu, F. Lu, J. Liu, G. Wang, Z. Feng, and Q. Hu Warm induction cardioplegia and reperfusion dose influence the occurrence of the post CABG TnI level Interactive CardioVascular and Thoracic Surgery, February 1, 2006; 5(1): 67 - 70. [Abstract] [Full Text] [PDF]

				F. F. Immer, C. Pirovino, E. Gygax, L. Englberger, H. Tevaearai, and T. P. Carrel Minimal versus conventional cardiopulmonary bypass: assessment of intraoperative myocardial damage in coronary bypass surgery Eur. J. Cardiothorac. Surg., November 1, 2005; 28(5): 701 - 704. [Abstract] [Full Text] [PDF]

				K. Alwan, P.-E. Falcoz, J. Alwan, W. Mouawad, G. Oujaimi, S. Chocron, and J.-P. Etievent Beating versus arrested heart coronary revascularization: evaluation by cardiac troponin I release Ann. Thorac. Surg., June 1, 2004; 77(6): 2051 - 2055. [Abstract] [Full Text] [PDF]

				F. Onorati, A. Renzulli, M. De Feo, G. Santarpino, R. Gregorio, A. Biondi, F. Cerasuolo, and M. Cotrufo Does antegrade blood cardioplegia alone provide adequate myocardial protection in patients with left main stem disease? J. Thorac. Cardiovasc. Surg., November 1, 2003; 126(5): 1345 - 1351. [Abstract] [Full Text] [PDF]

				J. B. Ryan, M. Hicks, J. R. Cropper, S. R. Garlick, S. H. Kesteven, M. K. Wilson, M. P. Feneley, and P. S. Macdonald The initial rate of troponin I release post-reperfusion reflects the effectiveness of myocardial protection during cardiac allograft preservation Eur. J. Cardiothorac. Surg., June 1, 2003; 23(6): 898 - 906. [Abstract] [Full Text] [PDF]

				P.-E. Falcoz, D. Kaili, S. Chocron, G. Toubin, M. Puyraveau, J.-F. Viel, and J.-P. Etievent Warm and tepid cardioplegia: Do they provide equal myocardial protection? Ann. Thorac. Surg., December 1, 2002; 74(6): 2156 - 2160. [Abstract] [Full Text] [PDF]

				O. P. Elvenes, C. Korvald, R. Myklebust, and D. Sorlie Warm retrograde blood cardioplegia saves more ischemic myocardium but may cause a functional impairment compared to cold crystalloid Eur. J. Cardiothorac. Surg., September 1, 2002; 22(3): 402 - 409. [Abstract] [Full Text] [PDF]

				Y. Yan, S. Davani, S. Chocron, B. Kantelip, P. Muret, and J.-P. Kantelip Effects of L-arginine administration before cardioplegic arrest on ischemia-reperfusion injury Ann. Thorac. Surg., December 1, 2001; 72(6): 1985 - 1990. [Abstract] [Full Text] [PDF]

				J. S. Raman, R. Bellomo, M. Hayhoe, M. Tsamitros, and B. F. Buxton Metabolic changes and myocardial injury during cardioplegia: a pilot study Ann. Thorac. Surg., November 1, 2001; 72(5): 1566 - 1571. [Abstract] [Full Text] [PDF]

				P. Eigel, G. van Ingen, and S. Wagenpfeil Predictive value of perioperative cardiac Troponin I for adverse outcome in coronary artery bypass surgery Eur. J. Cardiothorac. Surg., September 1, 2001; 20(3): 544 - 549. [Abstract] [Full Text] [PDF]

				J. C.J.M. Swaanenburg, B. G. Loef, M. Volmer, P. W. Boonstra, J. G. Grandjean, M. A. Mariani, and A. H. Epema Creatine Kinase MB, Troponin I, and Troponin T Release Patterns after Coronary Artery Bypass Grafting with or without Cardiopulmonary Bypass and after Aortic and Mitral Valve Surgery Clin. Chem., March 1, 2001; 47(3): 584 - 587. [Full Text] [PDF]

				E. Kilger, B. Pichler, F. Weis, A. Goetz, P. Lamm, A. Schutz, D. Muehlbayer, and L. Frey Markers of myocardial ischemia after minimally invasive and conventional coronary operation Ann. Thorac. Surg., December 1, 2000; 70(6): 2023 - 2028. [Abstract] [Full Text] [PDF]

				E. Vermes, M. Mesguich, R. Houel, C. Soustelle, P. Le Besnerais, M.-L. Hillion, and D. Loisance Cardiac troponin I release after open heart surgery: a marker of myocardial protection? Ann. Thorac. Surg., December 1, 2000; 70(6): 2087 - 2090. [Abstract] [Full Text] [PDF]

				G. Boriani, M. Biffi, V. Cervi, G. Bronzetti, G. Magagnoli, R. Zannoli, and A. Branzi Evaluation of Myocardial Injury Following Repeated Internal Atrial Shocks by Monitoring Serum Cardiac Troponin I Levels Chest, August 1, 2000; 118(2): 342 - 347. [Abstract] [Full Text] [PDF]

				S. Chocron and J.-P. Etievent Warm reperfusion as an adjunct to myocardial protection J. Thorac. Cardiovasc. Surg., May 1, 2000; 119(5): 1078 - 1078. [Full Text]

				S. Chocron, D. Kaili, Y. Yan, G. Toubin, L. Latini, F. Clement, J.-F. Viel, and J.-P. Etievent INTERMEDIATE LUKEWARM (20{degrees}C) ANTEGRADE INTERMITTENT BLOOD CARDIOPLEGIA COMPARED WITH COLD AND WARM BLOOD CARDIOPLEGIA J. Thorac. Cardiovasc. Surg., March 1, 2000; 119(3): 610 - 616. [Abstract] [Full Text] [PDF]

				M. Carrier, M. Pellerin, L. P. Perrault, B. C. Solymoss, and L. C. Pelletier Troponin levels in patients with myocardial infarction after coronary artery bypass grafting Ann. Thorac. Surg., February 1, 2000; 69(2): 435 - 440. [Abstract] [Full Text] [PDF]

				D. Belhomme, J. Peynet, M. Louzy, J.-M. Launay, M. Kitakaze, and P. Menasche Evidence for Preconditioning by Isoflurane in Coronary Artery Bypass Graft Surgery Circulation, November 9, 1999; 100 (2009): II-340 - II-344. [Abstract] [Full Text] [PDF]

				S. Wan, J.-L. LeClerc, M. Antoine, J.-M. DeSmet, A. P.C. Yim, and J.-L. Vincent Heparin-coated circuits reduce myocardial injury in heart or heart-lung transplantation: a prospective, randomized study Ann. Thorac. Surg., October 1, 1999; 68(4): 1230 - 1235. [Abstract] [Full Text] [PDF]

				M. Hendrikx, H. Jiang, H. Gutermann, J. Toelsie, D. Renard, A. Briers, J. L. Pauwels, and U. Mees RELEASE OF CARDIAC TROPONIN I IN ANTEGRADE CRYSTALLOID VERSUS COLD BLOOD CARDIOPLEGIA J. Thorac. Cardiovasc. Surg., September 1, 1999; 118(3): 452 - 459. [Abstract] [Full Text] [PDF]

				L.-W. Chen Troponin I and autotransfusion of shed mediastinal blood in redo cardiac operation Ann. Thorac. Surg., August 1, 1999; 68(2): 629 - 630. [Full Text] [PDF]

				A. H.B. Wu, F. S. Apple, W. B. Gibler, R. L. Jesse, M. M. Warshaw, and R. Valdes Jr. National Academy of Clinical Biochemistry Standards of Laboratory Practice: Recommendations for the Use of Cardiac Markers in Coronary Artery Diseases Clin. Chem., July 1, 1999; 45(7): 1104 - 1121. [Abstract] [Full Text] [PDF]

				D. J. Newman, Y. Olabiran, W. D. Bedzyk, S. Chance, E. G. Gorman, and C. P. Price Impact of Antibody Specificity and Calibration Material on the Measure of Agreement between Methods for Cardiac Troponin I Clin. Chem., June 1, 1999; 45(6): 822 - 828. [Abstract] [Full Text] [PDF]

				M. Caputo, W.C. Dihmis, A.J. Bryan, M.-S. Suleiman, and G.D. Angelini Warm blood hyperkalaemic reperfusion (`hot shot') prevents myocardial substrate derangement in patients undergoing coronary artery bypass surgery Eur. J. Cardiothorac. Surg., May 1, 1999; 13(5): 559 - 564. [Abstract] [Full Text] [PDF]

				R. Ascione, C. T. Lloyd, W. J. Gomes, M. Caputo, A. J. Bryan, and G. D. Angelini Beating versus arrested heart revascularization: evaluation of myocardial function in a prospective randomized study Eur. J. Cardiothorac. Surg., May 1, 1999; 15(5): 685 - 690. [Abstract] [Full Text] [PDF]

				L. Jacquet, P. Noirhomme, G. El Khoury, M. Goenen, M. Philippe, J. Col, and R. Dion Cardiac troponin I as an early marker of myocardial damage after coronary bypass surgery Eur. J. Cardiothorac. Surg., April 1, 1999; 13(4): 378 - 384. [Abstract] [Full Text] [PDF]

				I. Giuliani, J.-P. Bertinchant, C. Granier, M. Laprade, S. Chocron, G. Toubin, J.-P. Etievent, C. Larue, and S. Trinquier Determination of Cardiac Troponin I Forms in the Blood of Patients with Acute Myocardial Infarction and Patients Receiving Crystalloid or Cold Blood Cardioplegia Clin. Chem., February 1, 1999; 45(2): 213 - 222. [Abstract] [Full Text] [PDF]

				S. Chocron, K. Alwan, Y. Yan, G. Toubin, D. Kaili, T. Anguenot, L. Latini, F. Clement, J.-F. Viel, and J.-P. Etievent Warm reperfusion and myocardial protection Ann. Thorac. Surg., December 1, 1998; 66(6): 2003 - 2007. [Abstract] [Full Text] [PDF]

				G. Babatasi, M. Massetti, P. Nataf, S. Fradin, D. Agostini, G. Grollier, J.-L. Gerard, and A. Khayat Minimally invasive coronary surgery: surgical considerations and assessment of cardiac troponin I Eur. J. Cardiothorac. Surg., October 1, 1998; 14(suppl_1): S82 - S87. [Abstract] [Full Text] [PDF]

				M. Carrier, M. Pellerin, P. L. Page, N. R. Searle, R. Martineau, C. Caron, B. C. Solymoss, and L. C. Pelletier Can L-arginine improve myocardial protection during cardioplegic arrest? Results of a phase I pilot study Ann. Thorac. Surg., July 1, 1998; 66(1): 108 - 112. [Abstract] [Full Text] [PDF]

				R. Hirsch, C. L. Dent, M. K. Wood, C. B. Huddleston, E. N. Mendeloff, D. T. Balzer, Y. Landt, C. A. Parvin, M. Landt, J. H. Ladenson, et al. Patterns and Potential Value of Cardiac Troponin I Elevations After Pediatric Cardiac Operations Ann. Thorac. Surg., May 1, 1998; 65(5): 1394 - 1399. [Abstract] [Full Text] [PDF]

				I. Birdi, M Caputo, J. A. Hutter, A. J. Bryan, and G. D. Angelini TROPONIN I RELEASE DURING MINIMALLY INVASIVE CORONARY ARTERY SURGERY J. Thorac. Cardiovasc. Surg., September 1, 1997; 114(3): 509 - 510. [Full Text]

				I. Birdi, G. D. Angelini, and A. J. Bryan Biochemical Markers of Myocardial Injury During Cardiac Operations Ann. Thorac. Surg., March 1, 1997; 63(3): 879 - 884. [Abstract] [Full Text]

				S. Chocron, K. Alwan, G. Toubin, F. Clement, D. Kaili, C. Taberlet, A. Cordier, and J.-P. Etievent Crystalloid Cardioplegia Route of Delivery and Cardiac Troponin I Release Ann. Thorac. Surg., August 1, 1996; 62(2): 481 - 485. [Abstract] [Full Text]

				S. Chocron, K. Alwan, G. Toubin, B. Kantelip, F. Clement, J.-P. Kantelip, and J.-P. Etievent EFFECTS OF MYOCARDIAL ISCHEMIA ON THE RELEASE OF CARDIAC TROPONIN I IN ISOLATED RAT HEARTS J. Thorac. Cardiovasc. Surg., August 1, 1996; 112(2): 508 - 513. [Abstract] [Full Text]

				M. Hossein-Nia, D. W. Holt, J. R. Anderson, A. J. Murday, J.-P. Etievent, and S. Chocron Cardiac troponin I release in heart transplantation. Ann. Thorac. Surg., January 1, 1996; 61(1): 277 - 278. [Full Text]